Involvement of XZFP36L1, an RNA-binding protein,in Xenopus neural development
文献类型：期刊论文
| 作者 | Xia YJ1,2; Zhao SH3; Mao BY[*]1 |
| 刊名 | Zoological Research
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:E5−6页码:E82−E88 |
| 关键词 | ZFP36L1 RNA-binding protein Neural development Xenopus Post-transcriptional regulation |
| 通讯作者 | mao@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Xenopus ZFP36L1 (zinc finger protein 36, C3H type-like 1) belongs to the ZFP36 family of RNA-binding proteins, which contains two characteristic tandem CCCH-type zinc-finger domains. The ZFP36 proteins can bind AU-rich elements in 3' untranslated regions of target mRNAs and promote their turnover. However, the expression and role of ZFP36 genes during neural development in Xenopus embryos remains largely unknown. The present study showed that Xenopus ZFP36L1 was expressed at the dorsal part of the forebrain, forebrain-midbrain boundary, and midbrain-hindbrain boundary from late neurula stages to tadpole stages of embryonic development. Overexpression of XZFP36L1 in Xenopus embryos inhibited neural induction and differentiation, leading to severe neural tube defects. The function of XZP36L1 requires both its zinc finger and C terminal domains, which also affect its subcellular localization. These results suggest that XZFP36L1 is likely involved in neural development in Xenopus and might play an important role in post-transcriptional regulation. |
| 收录类别 | 其他 |
| 资助信息 | This work was supported by National Natural Science Foundation of China (90919039; C120106) |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7641]  |
| 专题 | 昆明动物研究所_发育生物学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China 2.Graduate University of Chinese Academy of Sciences, Beijing 100049, China 3.Yunnan Key Laboratory of Fertility Regulation and Minority Eugenics, Yunnan Population and Family Planning Research Institute, Kunming 650021, China |
| 推荐引用方式 GB/T 7714 | Xia YJ,Zhao SH,Mao BY[*]. Involvement of XZFP36L1, an RNA-binding protein,in Xenopus neural development[J]. Zoological Research,2012,33(E5−6):E82−E88. |
| APA | Xia YJ,Zhao SH,&Mao BY[*].(2012).Involvement of XZFP36L1, an RNA-binding protein,in Xenopus neural development.Zoological Research,33(E5−6),E82−E88. |
| MLA | Xia YJ,et al."Involvement of XZFP36L1, an RNA-binding protein,in Xenopus neural development".Zoological Research 33.E5−6(2012):E82−E88. |
入库方式： OAI收割
来源：昆明动物研究所
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