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The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin
文献类型：期刊论文
| 作者 | Ma PC1; Yang XC1,2; Kong QH1; Li CC1; Yang SJ3; Li Y4; Mao BY[*]1 |
| 刊名 | MOLECULAR AND CELLULAR BIOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 34期号:23页码:4355-4366 |
| 通讯作者 | mao@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Wnt/beta-catenin signaling plays critical roles in embryonic development and disease. Here, we identify RNF220, a RING domain E3 ubiquitin ligase, as a new regulator of beta-catenin. RNF220 physically interacts with beta-catenin, but instead of promoting its ubiquitination and proteasomal degradation, it stabilizes beta-catenin and promotes canonical Wnt signaling. Our analysis showed that RNF220 interacts with USP7, a ubiquitin-specific peptidase, which is required for RNF220 to stabilize beta-catenin. The RNF220/USP7 complex deubiquitinates beta-catenin and enhances canonical Wnt signaling. Interestingly, the stability of RNF220 itself is negatively regulated by Gsk3 beta, which is a key component of the beta-catenin destruction complex and is inhibited upon Wnt stimulation. Accordingly, the RNF220/USP7 complex works as a positive feedback regulator of beta-catenin signaling. In colon cancer cells with stimulated Wnt signaling, knockdown of RNF220 or USP7 impairs Wnt signaling and expression of Wnt target genes, suggesting a potentially novel role of RNF220 in Wnt-related tumorigenesis. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China (31171404) and West Light Foundation of the Chi- nese Academy of Sciences. |
| 语种 | 英语 |
| WOS记录号 | WOS:000344631500011 |
| 公开日期 | 2014-12-05 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8187]  |
| 专题 | 昆明动物研究所_发育生物学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology 2.Kunming College of Life Science, University of Chinese Academy of Sciences 3.Kunming Biological Diversity Regional Center of Large Apparatus and Equipments, Kunming Institute of Zoology 4.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, d Kunming, China |
| 推荐引用方式 GB/T 7714 | Ma PC,Yang XC,Kong QH,et al. The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin[J]. MOLECULAR AND CELLULAR BIOLOGY,2014,34(23):4355-4366. |
| APA | Ma PC.,Yang XC.,Kong QH.,Li CC.,Yang SJ.,...&Mao BY[*].(2014).The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin.MOLECULAR AND CELLULAR BIOLOGY,34(23),4355-4366. |
| MLA | Ma PC,et al."The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin".MOLECULAR AND CELLULAR BIOLOGY 34.23(2014):4355-4366. |
入库方式： OAI收割
来源：昆明动物研究所
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