A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation
文献类型：期刊论文
| 作者 | Jiang SY1,3; Du JC1,3; Kong QH2; Li YC2; Sun HD2; Li CC1; Pu JX[*]2; Mao BY[*]1 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2015 |
| 卷号 | 10期号:10页码:e0139830 |
| 通讯作者 | pujianxin@mail.kib.ac.cn ; mao@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The Hedgehog (Hh) signaling pathway plays important roles in the tumorigenesis of multiple cancers and is a key target for drug discovery. In a screen of natural products extracted from Chinese herbs, we identified eight ent-Kaurane diterpenoids and two triterpene dilactones as novel Hh pathway antagonists. Epistatic analyses suggest that these compounds likely act at the level or downstream of Smoothened (Smo) and upstream of Suppressor of Fused (Sufu). The ent-Kauranoid-treated cells showed elongated cilia, suppressed Smo trafficking to cilia, and mitotic defects, while the triterpene dilactones had no effect on the cilia and ciliary Smo. These ent-Kaurane diterpenoids provide new prototypes of Hh inhibitors, and are valuable probes for deciphering the mechanisms of Smo ciliary transport and ciliogenesis. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by NSFC-Yunnan Joint Funds (U1302226 and U1302223), and National Natural Science Foundation of China (21322204). |
| 语种 | 中文 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9422]  |
| 专题 | 昆明动物研究所_发育生物学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China |
| 推荐引用方式 GB/T 7714 | Jiang SY,Du JC,Kong QH,et al. A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation[J]. PLOS ONE,2015,10(10):e0139830. |
| APA | Jiang SY.,Du JC.,Kong QH.,Li YC.,Sun HD.,...&Mao BY[*].(2015).A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation.PLOS ONE,10(10),e0139830. |
| MLA | Jiang SY,et al."A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation".PLOS ONE 10.10(2015):e0139830. |
入库方式： OAI收割
来源：昆明动物研究所
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