Elongator Protein 3 (Elp3) stabilizes Snail1 and regulates neural crest migration in Xenopus
文献类型：期刊论文
| 作者 | Yang XC1,2; Li JJ3; Zeng WL4; Li CC1; Mao BY[*]1 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:X页码:e26238 |
| 通讯作者 | mao@mail.kiz.ac.cn |
| 英文摘要 | Elongator protein 3 (Elp3) is the enzymatic unit of the elongator protein complex, a histone acetyltransferase complex involved in transcriptional elongation. It has long been shown to play an important role in cell migration; however, the underlying mechanism is unknown. Here, we showed that Elp3 is expressed in pre-migratory and migrating neural crest cells in Xenopus embryos, and knockdown of Elp3 inhibited neural crest cell migration. Interestingly, Elp3 binds Snail1 through its zinc-finger domain and inhibits its ubiquitination by β-Trcp without interfering with the Snail1/Trcp interaction. We showed evidence that Elp3-mediated stabilization of Snail1 was likely involved in the activation of N-cadherin in neural crest cells to regulate their migratory ability. Our findings provide a new mechanism for the function of Elp3 in cell migration through stabilizing Snail1, a master regulator of cell motility. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by a grant from the CAS Key Project (KJZD-EW-L08). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9874]  |
| 专题 | 昆明动物研究所_发育生物学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, 650203, China 3.Center of Molecular Diagnostics, The Affiliated Hospital of KMUST, Medical School, Kunming University of Science and Technology, Kunming 650032, China 4.China Tobacco Yunnan Industrial Co., Ltd., Kunming, 650024, China |
| 推荐引用方式 GB/T 7714 | Yang XC,Li JJ,Zeng WL,et al. Elongator Protein 3 (Elp3) stabilizes Snail1 and regulates neural crest migration in Xenopus[J]. SCIENTIFIC REPORTS,2016,6(X):e26238. |
| APA | Yang XC,Li JJ,Zeng WL,Li CC,&Mao BY[*].(2016).Elongator Protein 3 (Elp3) stabilizes Snail1 and regulates neural crest migration in Xenopus.SCIENTIFIC REPORTS,6(X),e26238. |
| MLA | Yang XC,et al."Elongator Protein 3 (Elp3) stabilizes Snail1 and regulates neural crest migration in Xenopus".SCIENTIFIC REPORTS 6.X(2016):e26238. |
入库方式： OAI收割
来源：昆明动物研究所
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