中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Human immunodeficiency virus-1 genotypic

文献类型:期刊论文

作者Liu XL1,2; Xia YJ1; Ma FC[*]1; Ma BY[*]1; Tang JX1; Ma L1; Li CC1
刊名The Journal of Biological Chemistry
出版日期2017
卷号X期号:X页码:XX-XX
关键词Xenopus embryo neurodevelopment chromatin remodeling cell differentiation Akirin2 BAF53a Geminin
通讯作者kunmapch@mail.kiz.ac.cn ; mao@mail.kiz.ac.cn
合作状况其它
英文摘要To ensure correct spatial and temporal patterning, embryos must maintain pluripotent cell populations and control when cells undergo commitment. The newly identified nucleoprotein Akirin has been shown to modulate the innate immune response through epigenetic regulation and to play important roles in other physiological processes, but its role in neural development remains unknown. Here, we show that Akirin2 is required for neural development in Xenopus and knockdown of Akirin2 expands the expression of the neural progenitor marker Sox2 and inhibits expression of the differentiated neuronal marker N-tubulin. Akirin2 acts antagonistically to Geminin, thus regulating Sox2 expression, and maintains the neural precursor state by participating in Brg1/Brm-associated factor (BAF) complex mediated by BAF53a. Additionally, Akirin2 also modulates N-tubulin expression by acting upstream of NeuroD and in parallel with Ngnr1 during terminal neuronal differentiation. Thus, our results reveal a novel model in which Akirin2 precisely coordinates and temporally controls Xenopus neural development.
收录类别SCI
资助信息This work was supported by grants from the National Natural Science Foundation of China (No. 31171404 to B.Y.M).
语种英语
源URL[http://159.226.149.26:8080/handle/152453/10850]  
专题昆明动物研究所_发育生物学
昆明动物研究所_遗传资源与进化国家重点实验室
作者单位1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650203, China
推荐引用方式
GB/T 7714
Liu XL,Xia YJ,Ma FC[*],et al. Human immunodeficiency virus-1 genotypic[J]. The Journal of Biological Chemistry,2017,X(X):XX-XX.
APA Liu XL.,Xia YJ.,Ma FC[*].,Ma BY[*].,Tang JX.,...&Li CC.(2017).Human immunodeficiency virus-1 genotypic.The Journal of Biological Chemistry,X(X),XX-XX.
MLA Liu XL,et al."Human immunodeficiency virus-1 genotypic".The Journal of Biological Chemistry X.X(2017):XX-XX.

入库方式: OAI收割

来源:昆明动物研究所

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