Dual roles of Akirin2 during Xenopus neural development
文献类型：期刊论文
| 作者 | Liu XL1,2; Xia YJ1,3; Ma PC[*]1; Ma BY[*]1; Tang JX1,4; Ma L1,5; Li CC1 |
| 刊名 | The Journal of Biological Chemistry
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:in Press,Published online |
| 关键词 | Xenopus embryo neurodevelopment chromatin remodeling cell differentiation Akirin2, BAF53a Geminin |
| 通讯作者 | kunmapch@mail.kiz.ac.cn |
| 英文摘要 | To ensure correct spatial and temporal patterning, embryos must maintain pluripotent cell populations and control when cells undergo commitment. The newly identified nucleoprotein Akirin has been shown to modulate the innate immune response through epigenetic regulation and to play important roles in other physiological processes, but its role in neural development remains unknown. Here, we show that Akirin2 is required for neural development in Xenopus and knockdown of Akirin2 expands the expression of the neural progenitor marker Sox2 and inhibits expression of the differentiated neuronal marker N-tubulin. Akirin2 acts antagonistically to Geminin, thus regulating Sox2 expression, and maintains the neural precursor state by participating in Brg1/Brm-associated factor (BAF) complex mediated by BAF53a. Additionally, Akirin2 also modulates N-tubulin expression by acting upstream of NeuroD and in parallel with Ngnr1 during terminal neuronal differentiation. Thus, our results reveal a novel model in which Akirin2 precisely coordinates and temporally controls Xenopus neural development. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China (No. 31171404 to B.Y.M). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10851]  |
| 专题 | 昆明动物研究所_发育生物学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650203, China 3.Present address: Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. 4.Present address: State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China 5.Present address: Department of Biology, University of Maryland, College Park, MD 20742, USA |
| 推荐引用方式 GB/T 7714 | Liu XL,Xia YJ,Ma PC[*],et al. Dual roles of Akirin2 during Xenopus neural development[J]. The Journal of Biological Chemistry,2017,**(**):in Press,Published online. |
| APA | Liu XL.,Xia YJ.,Ma PC[*].,Ma BY[*].,Tang JX.,...&Li CC.(2017).Dual roles of Akirin2 during Xenopus neural development.The Journal of Biological Chemistry,**(**),in Press,Published online. |
| MLA | Liu XL,et al."Dual roles of Akirin2 during Xenopus neural development".The Journal of Biological Chemistry **.**(2017):in Press,Published online. |
入库方式： OAI收割
来源：昆明动物研究所
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