Expression of adhesion molecules and mucins in human and rhesus macaque gastrointestinal epithelial cells
文献类型：期刊论文
| 作者 | Zhang HY1,2,3; Chang H1,2; Fan XN1; Zhang KD1,2; Yu L4; Cao Y[*]1 |
| 刊名 | HISTOLOGY AND HISTOPATHOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 26期号:11页码:1405-1413 |
| 关键词 | Adhesion molecule Mucin Gastrointestinal epithelium Carcinoma Rhesus macaque |
| 通讯作者 | caoy@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Epithelial junctions and mucins play key roles in the gastrointestinal mucosal barrier, and their alterations are associated with numerous diseases, including carcinomas. The systematic expression of adhesion molecules and mucins in normal and malignant human gastrointestinal cells was investigated in this study. In normal human gastrointestinal cells, zonula occludens-1 (ZO-1), alpha-catenin, beta-catenin, gamma-catenin and desmoglein-2 (DSG2) were located in the cytoplasmic membranes, whereas symplekin stained in the nuclei. ZO-1, the three catenins, and DSG2 were observed in the gastric and colorectal carcinomas with reduced and heterogeneous expression and with abnormal distribution. Symplekin was detected in the nuclei of tumor cells in most tumors but not observed in some others. The immunohistochemical results for ZO-1 and symplekin on the tissues were consistent with the data for the cultured cells obtained by immunocytochemical staining and Western blot analysis. MUC1 was not stained in the normal gastrointestinal cells without periodate oxidation, but it was strongly labeled in the malignant gastrointestinal cells. MUC2 was detected in the normal and malignant gastrointestinal cells without the periodate treatment. These findings indicate that alterations in the expression of the epithelial junctions and mucins are associated with the malignant transformation of gastrointestinal cells. In addition, the gastrointestinal epithelial cells of rhesus macaques expressed these adhesion molecules and mucins, as did the human cells, suggesting that the rhesus monkey is a suitable experimental animal model for research on adhesion molecules and mucins. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China (No. 30800407) and the Chinese Academy of Sciences (KSCX2-YW-R-092). |
| 语种 | 英语 |
| 公开日期 | 2011-10-20 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6819]  |
| 专题 | 昆明动物研究所_分子病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of CAS and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Graduate University of the Chinese Academy of Sciences, Beijing, China 3.Department of Gastroenterology, Kunming First People’s Hospital, Kunming, China 4.Department of Pathology, Kunming First People’s Hospital, Kunming, China |
| 推荐引用方式 GB/T 7714 | Zhang HY,Chang H,Fan XN,et al. Expression of adhesion molecules and mucins in human and rhesus macaque gastrointestinal epithelial cells[J]. HISTOLOGY AND HISTOPATHOLOGY,2011,26(11):1405-1413. |
| APA | Zhang HY,Chang H,Fan XN,Zhang KD,Yu L,&Cao Y[*].(2011).Expression of adhesion molecules and mucins in human and rhesus macaque gastrointestinal epithelial cells.HISTOLOGY AND HISTOPATHOLOGY,26(11),1405-1413. |
| MLA | Zhang HY,et al."Expression of adhesion molecules and mucins in human and rhesus macaque gastrointestinal epithelial cells".HISTOLOGY AND HISTOPATHOLOGY 26.11(2011):1405-1413. |
入库方式： OAI收割
来源：昆明动物研究所
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