Exposure to morphine affects the expression of endocannabinoid receptors and immune functions
文献类型：期刊论文
| 作者 | Zhang QY1,2; Zhang M1,2; Cao Y[*]1 |
| 刊名 | JOURNAL OF NEUROIMMUNOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 247期号:1-2页码:52-58 |
| 关键词 | Morphine abuse Cannabinoid receptor Opioid receptor Immune cells Immune function |
| 通讯作者 | caoy@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Compared with control rats, rats under morphine exposure exhibited cannabinoid receptor 2 (CB2-R) upregulation in the spleen and periphery blood mononuclear cells (PBMCs). IgG and IgM values in the plasma were also altered. In morphine abusers, cannabinoid receptors were upregulated in the PBMCs, and the expression of IL-4 mRNA in the PBMCs as well as the IgG and IgM values in the plasma were higher compared with those in healthy people. The expression of cannabinoid receptor 1 and CB2-R in culture cells was directly affected by morphine treatment. These findings indicate that the alteration in cannabinoid receptor expression could be disturbed by morphine exposure, and it may be involved in abnormal immune function. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese Academy of Sciences (KSCX2-YW-R- 092) and Key Laboratory of Animal Models and Human Disease Mecha- nism of CAS and Yunnan Province. |
| 语种 | 英语 |
| 公开日期 | 2012-09-07 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7055]  |
| 专题 | 昆明动物研究所_分子病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Laboratory of Molecular and Experimental Pathology, Key Laboratory of Animal Models and Human Disease Mechanisms of CAS and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, People's Republic of China 2.Graduate University of the Chinese Academy of Sciences, Beijing, People's Republic of China |
| 推荐引用方式 GB/T 7714 | Zhang QY,Zhang M,Cao Y[*]. Exposure to morphine affects the expression of endocannabinoid receptors and immune functions[J]. JOURNAL OF NEUROIMMUNOLOGY,2012,247(1-2):52-58. |
| APA | Zhang QY,Zhang M,&Cao Y[*].(2012).Exposure to morphine affects the expression of endocannabinoid receptors and immune functions.JOURNAL OF NEUROIMMUNOLOGY,247(1-2),52-58. |
| MLA | Zhang QY,et al."Exposure to morphine affects the expression of endocannabinoid receptors and immune functions".JOURNAL OF NEUROIMMUNOLOGY 247.1-2(2012):52-58. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。