Basal physiological parameters in domesticated tree shrews (Tupaia belangeri chinensis)
文献类型：期刊论文
| 作者 | Wang J1,3; Xu XL1,3; Ding ZY1,4; Mao RR1; Zhou QX1; Lv LB2; Wang LP1; Wang SS1; Zhang C1,5; Xu L1,6 |
| 刊名 | Zoological Research
 |
| 出版日期 | 2013 |
| 卷号 | 34期号:E2页码:E69−E74 |
| 关键词 | Domesticated tree shrew Basal physiological indexes Rhythm Glycometabolism Stress-related hormone |
| 通讯作者 | yangyx0553@yahoo.com.cn |
| 合作状况 | 其它 |
| 英文摘要 | Establishing non-human primate models of human diseases is an efficient way to narrow the large gap between basic studies and translational medicine. Multifold advantages such as simplicity of breeding, low cost of feeding and facility of operating make the tree shrew an ideal non-human primate model proxy. Additional features like vulnerability to stress and spontaneous diabetic characteristics also indicate that the tree shrew could be a potential new animal model of human diseases. However, basal physiological indexes of tree shrew, especially those related to human disease, have not been systematically reported. Accordingly, we established important basal physiological indexes of domesticated tree shrews including several factors: (1) body weight, (2) core body temperature and rhythm, (3) diet metabolism, (4) locomotor rhythm, (5) electroencephalogram, (6) glycometabolism and (7) serum and urinary hormone level and urinary cortisol rhythm. We compared the physiological parameters of domesticated tree shrew with that of rats and macaques. Results showed that (a) the core body temperature of the tree shrew was 39.59 +/- 0.05 degrees C, which was higher than that of rats and macaques; (b) Compared with wild tree shrews, with two activity peaks, domesticated tree shrews had only one activity peak from 17: 30 to 19: 30; (c) Compared with rats, tree shrews had poor carbohydrate metabolism ability; and (d) Urinary cortisol rhythm indicated there were two peaks at 8: 00 and 17: 00 in domesticated tree shrews, which matched activity peaks in wild tree shrews. These results provided basal physiological indexes for domesticated tree shrews and laid an important foundation for diabetes and stress-related disease models established on tree shrews. |
| 收录类别 | 其他 |
| 资助信息 | This work was supported by grants from the Chinese Academy of Sciences (KSCX2-EW-R-12, KSCX2-EW-J-23), the National Natural Science Foundation of China (81171294) and Shanghai Science & Technology Development Foundation (12140904200). |
| 语种 | 英语 |
| 公开日期 | 2013-06-14 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7476]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_分子病理学 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.University of Chinese Academy of Sciences, Beijing 100049, China 4.School of Life Sciences, Anhui University, Hefei 230601, China 5.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China 6.Tree Shrew Inbreeding Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Wang J,Xu XL,Ding ZY,et al. Basal physiological parameters in domesticated tree shrews (Tupaia belangeri chinensis)[J]. Zoological Research,2013,34(E2):E69−E74. |
| APA | Wang J.,Xu XL.,Ding ZY.,Mao RR.,Zhou QX.,...&Yang YX[*].(2013).Basal physiological parameters in domesticated tree shrews (Tupaia belangeri chinensis).Zoological Research,34(E2),E69−E74. |
| MLA | Wang J,et al."Basal physiological parameters in domesticated tree shrews (Tupaia belangeri chinensis)".Zoological Research 34.E2(2013):E69−E74. |
入库方式： OAI收割
来源：昆明动物研究所
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