Influence of BCL2 gene in major depression susceptibility and antidepressant treatment outcome
文献类型：期刊论文
| 作者 | Zhang C1,2; Wu ZG1; Hong W1; Wang ZW1,3; Peng DH1; Chen J1; Yuan CM1; Yu SY4; Xu L2; Fang YR[*]1 |
| 刊名 | JOURNAL OF AFFECTIVE DISORDERS
 |
| 出版日期 | 2014 |
| 卷号 | 155期号:X页码:288–294 |
| 关键词 | B-cell/lymphoma 2 Major depressive disorder Treatment-resistant depression Association |
| 通讯作者 | yirufang@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Background: Our recent work indicated that low expression of the anti-apoptotic protein B-cell/lymphoma 2 (Bc1-2) mRNA was observed among untreated major depressive disorder (MDD) patients, and the subsequent altered level of Bcl-2 was found to be close to the antidepressant treatment outcome. The primary aim of this present study was to examine whether a particular gene, encoding Bcl-2 (BCL2) confers risk to MDD, and likewise to investigate whether this gene acts as an indicator of antidepressant treatment outcome. Methods: We enrolled 178 treatment resistant depression (TRD) and 612 non-treatment-resistant depression (NTRD) patients as well as 725 healthy controls. In total, three selected Lagging SNPs (LagSNPs) of BCL2 (rs2279115, rs1801018 and rs1564483) were genotypecl to Lest for possible association. Using TaciMan relative quantitative real time polymerase chain reaction (PCR), we analyzed leukocytic expression of BCl2 mRNA in 47 healthy subjects. Results: Of the three SNPs, we observed 110 significant differences in genotype and allele frequencies between the MDD and control groups as well as between the TRD and NTRD groups. However, we found a significant association between the rs2279115C allele and TRD in males (corrected P=0.048) but not in Females. Further real-time quantitative PCR analysis in healthy subjects revealed that the rs2279115 polymorphism significantly influenced BCL2 iuRNA expression (P=0.03). Limitations: This is a preliminary investigation with relatively small sample size and cross-sectional design. Conclusions: These initial findings strengthen the hypothesis that BCL12may play an important role in mediating the outcome of antidepressant treatment, a result that may further be confirmed by future genetic studies from large-scale populations that can overcome the limited sample size of this preliminary finding. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (91232719), the “12th Five-year Plan” of National Key Technologies R&D Program (2012BAI01B04), the Shanghai Science & Technology Development Foundation (12140904200), the China Postdoctoral Science Foundation (2013M530410) and the National Key Clinical Disciplines at Shanghai Mental Health Center (OMA-MH2011-873). |
| 语种 | 英语 |
| 公开日期 | 2014-06-04 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7869]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_分子病理学 |
| 作者单位 | 1.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 3.Department of Psychiatry, Hongkou District Mental Health Center of Shanghai, Shanghai, China 4.Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China |
| 推荐引用方式 GB/T 7714 | Zhang C,Wu ZG,Hong W,et al. Influence of BCL2 gene in major depression susceptibility and antidepressant treatment outcome[J]. JOURNAL OF AFFECTIVE DISORDERS,2014,155(X):288–294. |
| APA | Zhang C.,Wu ZG.,Hong W.,Wang ZW.,Peng DH.,...&Fang YR[*].(2014).Influence of BCL2 gene in major depression susceptibility and antidepressant treatment outcome.JOURNAL OF AFFECTIVE DISORDERS,155(X),288–294. |
| MLA | Zhang C,et al."Influence of BCL2 gene in major depression susceptibility and antidepressant treatment outcome".JOURNAL OF AFFECTIVE DISORDERS 155.X(2014):288–294. |
入库方式： OAI收割
来源：昆明动物研究所
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