Estrogen receptor 1 gene rs2295193 polymorphism and anorexia nervosa: New data and meta-analysis
文献类型：期刊论文
| 作者 | Zhang C1,2; Chen J[*]1; Jia XZ1; Yu SY[1]1; Jiang WH1; Zhang R1; Yuan AH1; Qian YP1; Fan J1; Zhang MD1 |
| 刊名 | ASIA-PACIFIC PSYCHIATRY
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:4页码:331-335 |
| 关键词 | anorexia nervosa association estrogen receptor 1 gene meta-analysis polymorphism |
| 通讯作者 | chenjue2088@163.com ; xiaozeping@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | IntroductionEstrogen plays essential roles in the regulation of food intake, adiposity, and body weight control. The estrogen alpha receptor, encoded by estrogen receptor 1 gene (ESR1), has been implicated with anorexia nervosa (AN). A previous study indicated that the rs2295193 polymorphism in ESR1 may confer a genetic susceptibility to AN. MethodsIn a case-control study, we assessed 195 AN probands and 93 healthy controls; 99 trios were studied in a family-based association analysis through genotyping the rs2295193 polymorphism in ESR1. Additionally, we carried out a meta-analysis of the combined sample groups. ResultsThere were no significant differences in the genotype or allele frequencies of the rs2295193 polymorphism between the AN and control groups (Ps>0.05). In the transmission disequilibrium test (TDT) analyses, there was no evidence for biased transmission of the G allele of rs2295193 polymorphism (P=0.32). In female-only samples, no significant association was observed between the rs2295193 polymorphism and AN in either case-control or transmission disequilibrium test analyses (Ps>0.05). The meta-analysis revealed that no excess of transmission of the G allele in AN families (pooled odds ratio =1.10, P=0.79). DiscussionMeta-analytically combined evidence from the present genotyping and the literature showed that rs2295193 polymorphism in ESR1 is not a major genetic susceptibility factor in AN. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Founda- tion of China (81201055 to JC) and the National Key Clinical Disciplines at Shanghai Mental Health Center (OMA-MH2011-873 to YF). There is no conflict of interest. |
| 语种 | 英语 |
| WOS记录号 | WOS:000329800000014 |
| 公开日期 | 2014-09-28 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8016]  |
| 专题 | 昆明动物研究所_分子病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, China |
| 推荐引用方式 GB/T 7714 | Zhang C,Chen J[*],Jia XZ,et al. Estrogen receptor 1 gene rs2295193 polymorphism and anorexia nervosa: New data and meta-analysis[J]. ASIA-PACIFIC PSYCHIATRY,2013,5(4):331-335. |
| APA | Zhang C.,Chen J[*].,Jia XZ.,Yu SY[1].,Jiang WH.,...&Xiao ZP[*].(2013).Estrogen receptor 1 gene rs2295193 polymorphism and anorexia nervosa: New data and meta-analysis.ASIA-PACIFIC PSYCHIATRY,5(4),331-335. |
| MLA | Zhang C,et al."Estrogen receptor 1 gene rs2295193 polymorphism and anorexia nervosa: New data and meta-analysis".ASIA-PACIFIC PSYCHIATRY 5.4(2013):331-335. |
入库方式： OAI收割
来源：昆明动物研究所
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