MiRNA-206 and BDNF genes interacted in bipolar I disorder
文献类型：期刊论文
| 作者 | Wang ZW1,2; Zhang C[*]1,3; Huang J1; Yuan CM1; Hong W1; Chen J1; Yu SY4; Xu L3; Gao KM5; Fang YR[*]1 |
| 刊名 | JOURNAL OF AFFECTIVE DISORDERS
 |
| 出版日期 | 2014 |
| 卷号 | 162期号:X页码:116-119 |
| 关键词 | Mood stabilizer Treatment response Bipolar disorders MiRNA-206 Brain-derived neurotrophic factor |
| 通讯作者 | zhangchen645@gmail.com ; yirufang@aliyun.com |
| 英文摘要 | Background: Several lines of evidence have suggested that has-mir-206 (miRNA-206) may regulate brain derived neurotrophic factor (BDNF) protein synthesis. The primary aim of this study was to determine whether miRNA-206 gene (MIR206) may confer susceptibility to bipolar disorder type l (BD I) and treatment response to mood stabilizers. Also, we intended to verify the hypothesis that a potential interplay of MIR206 and BDNF may influence the genetic risk for BD-I and treatment response. Methods: The MIR206 rs16882131 and BDNF rs6265 polymorphisms were genotyped in 280 BD-I patients and 288 healthy controls. Treatment response to lithium and valproate was retrospectively determined. Results: No association was observed in the individual polymorphism with regards to risk of BD-I and treatment response. Our results showed a significant gene to gene interaction between the MIR206 516882131 and BDNF rs6265 polymorphisms that contribute to BD-I susceptibility and treatment response. Further analysis showed a significant interaction between MIR206 and BDNF on treatment score (F-3,F- 138=8.61, P=0.046), and individuals with MIR206 T/T+TC and BDNF A/A genotypes had a significantly lower mean treatment score than those with MIR206 CC and BDNF A/A+A/G as well as those with MIR206 CC and BDNF GIG genotypes (P=0.018 and 0.013, respectively). Limitation: This is a preliminary investigation with relatively small sample size. Conclusion: Our findings provide initial evidence of the gene-to-gene interaction of MIR206 and BDNF in regards to the risk for BD-I as well as treatment response to mood stabilizers |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (30971047, 91232719 and 81301159), the “12th Five-year Plan” of National Key Technologies R&D Program (2012BAI01B04), the Shanghai Science & Technology Development Foundation (12140904200), the Training Plan for Excellent Academic Leaders of Shanghai Health System (XBR2013087) and the National Key Clinical Disciplines at Shanghai Mental Health Center (OMA-MH2011-873). |
| 语种 | 英语 |
| WOS记录号 | WOS:000335386000021 |
| 公开日期 | 2014-10-15 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8037]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_分子病理学 |
| 作者单位 | 1.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2.Department of Psychiatry, Division of Mood Disorders, Hongkou District Mental Health Center of Shanghai, Shanghai, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming, Yunnan, China 4.Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, Chin 5.Mood and Anxiety Clinic in the Mood Disorders Program of the Department of Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, USA |
| 推荐引用方式 GB/T 7714 | Wang ZW,Zhang C[*],Huang J,et al. MiRNA-206 and BDNF genes interacted in bipolar I disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2014,162(X):116-119. |
| APA | Wang ZW.,Zhang C[*].,Huang J.,Yuan CM.,Hong W.,...&Fang YR[*].(2014).MiRNA-206 and BDNF genes interacted in bipolar I disorder.JOURNAL OF AFFECTIVE DISORDERS,162(X),116-119. |
| MLA | Wang ZW,et al."MiRNA-206 and BDNF genes interacted in bipolar I disorder".JOURNAL OF AFFECTIVE DISORDERS 162.X(2014):116-119. |
入库方式： OAI收割
来源：昆明动物研究所
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