Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype
文献类型：期刊论文
| 作者 | Zhang Y1; Chen MJ1; Chen J2; Wu ZG2; Yu SY3; Fang Y[*]2; Zhang C[*]1,4 |
| 刊名 | PSYCHOPHARMACOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 231期号:10页码:2211-2218 |
| 关键词 | Clozapine Triglyceride COMT Association Metabolic syndrome |
| 通讯作者 | yirufang@aliyun.com ; zhangchen645@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Metabolic syndrome (MetS) has consistently been identified as an adverse effect of long-term treatment with atypical antipsychotics (AAPs) such as clozapine. Elevated serum homocysteine concentration has been found to act as an independent risk factor for MetS, and catechol-O-methyltransferase (COMT) catalyzes the homocysteine metabolism. We accordingly hypothesized that COMT dysregulation may confer the susceptibility to MetS induced by AAPs, potentially in a gender-specific manner, because the interaction effects of COMT and gender have been consistently reported. This study aimed at determining the prevalence and influence of COMT on MetS among a population undergoing long-term clozapine treatment. A total of 468 schizophrenia patients taking clozapine were divided into two groups, those experiencing MetS and non-MetS. We genotyped three functional variants (rs4633, rs4680, and rs4818) in COMT and measured the serum levels of fasting homocysteine, glucose, triglyceride (TG), and high-density lipoprotein cholesterol. MetS was found in 202/468 (43.2 %) of all the patients, with 40.2 % prevalence (138/343) in males and 51.2 % (64/125) in females. Patients with MetS had notably higher metabolic parameters than those without MetS. The mean levels of homocysteine in patients with MetS were significantly higher than those without MetS. We found a positive association between the rs4680 polymorphism and the serum triglyceride levels (corrected P = 0.024). Further analysis revealed that the rs4680 Met allele was significantly associated with increased triglyceride levels among female patients (P = 0.009), but not among males (P = 0.07). Our findings suggest a potential association between rs4680 in COMT and elevated TG levels, particularly among female patients. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (81000581), the Shanghai Science & Tech- nologyDevelopmentFoundation(12140904200),theChinaPostdoctoral Science Foundation (2013M530410), and the National Key Clinical Disciplines at Shanghai Mental Health Center (OMA-MH, 2011-873). |
| 语种 | 英语 |
| WOS记录号 | WOS:000335166500015 |
| 公开日期 | 2014-10-15 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8050]  |
| 专题 | 昆明动物研究所_分子病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, Chin 2.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China 3.Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China 4.Key Laboratory of Animal Models andHuman Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Zhang Y,Chen MJ,Chen J,et al. Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype[J]. PSYCHOPHARMACOLOGY,2014,231(10):2211-2218. |
| APA | Zhang Y.,Chen MJ.,Chen J.,Wu ZG.,Yu SY.,...&Zhang C[*].(2014).Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype.PSYCHOPHARMACOLOGY,231(10),2211-2218. |
| MLA | Zhang Y,et al."Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype".PSYCHOPHARMACOLOGY 231.10(2014):2211-2218. |
入库方式： OAI收割
来源：昆明动物研究所
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