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A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression
文献类型：期刊论文
| 作者 | Zhang C1,2; Li ZZ3; Wu ZG1; Chen J1; Wang ZW1; Peng DH1; Hong W1; Yuan CM1; Wang Z4; Yu SY5 |
| 刊名 | PSYCHOPHARMACOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 231期号:4页码:685-693 |
| 关键词 | Treatment-resistant depression Genetic predictor GRIN2B Major depressive disorder |
| 通讯作者 | xiaozeping@gmail.com ; yirufang@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | In clinical practice, ketamine, an antagonist of the N-methyl-d-aspartate receptor (NMDAR), is used to alleviate depressive symptoms in patients with major depressive disorder (MDD), especially in those with treatment-resistant depression (TRD). Accordingly, the human gene coding for the 2B subunit of the NMDAR (GRIN2B) is considered a promising candidate gene for MDD susceptibility. The primary aim of this study is to examine whether potentially functional polymorphisms of GRIN2B confer risk for MDD, and second to investigate whether GRIN2B acts as a genetic predictor for TRD in MDD patients. We enrolled 178 TRD and 612 non-TRD patients as well as 779 healthy controls. Four potentially functional polymorphisms (rs1805502, rs890, rs1806201, and rs7301328) within GRIN2B were genotyped in all participants. The haplotype analysis found significant differences in the distribution of the G-T haplotype between the TRD and control groups (corrected P = 0.007), and the frequency of the G-T haplotype in TRD group was significantly higher than that in the controls (TRD/control ratio 0.31:0.21). Statistically significant differences in allele and genotype frequencies were detected between TRD and non-TRD groups for the rs1805502 polymorphism within GRIN2B. There was a significant allelic association between rs1805502 and TRD with an excess of the G allele in the TRD group, compared to non-TRD group (OR = 1.55, 95 % CI = 1.18-2.05, corrected P = 0.008). These initial findings strengthen the hypothesis that GRIN2B not only confers susceptibility to TRD, but also plays a genetic predictor for TRD in MDD patients. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (91232719), the “12th Five-year Plan” of National Key Technologies R&D Program (2012BAI01B04), the Shanghai Science & Technology Development Foundation (12140904200) and the National Key Clinical DisciplinesatShanghaiMentalHealthCenter(OMA-MH2011-873). |
| 语种 | 英语 |
| WOS记录号 | WOS:000330983500006 |
| 公开日期 | 2014-10-16 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8060]  |
| 专题 | 昆明动物研究所_分子病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China 2.Key Laboratory of Animal Models andHuman Disease Mechanisms oftheChineseAcademyofSciencesandYunnanProvince,Kunming Institute of Zoology, Kunming 650223, Yunnan, China 3.Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai 200433, China 4.Department of Clinical Psychology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China 5.Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China |
| 推荐引用方式 GB/T 7714 | Zhang C,Li ZZ,Wu ZG,et al. A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression[J]. PSYCHOPHARMACOLOGY,2014,231(4):685-693. |
| APA | Zhang C.,Li ZZ.,Wu ZG.,Chen J.,Wang ZW.,...&Fang YR[*].(2014).A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression.PSYCHOPHARMACOLOGY,231(4),685-693. |
| MLA | Zhang C,et al."A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression".PSYCHOPHARMACOLOGY 231.4(2014):685-693. |
入库方式： OAI收割
来源：昆明动物研究所
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