Does the Bipolar Disorder-Associated CACNA1C Gene Confer Susceptibility to Schizophrenia in Han Chinese?
文献类型：期刊论文
| 作者 | Zhang JT1; Cai J2; Zhang X3; Ni JL1; Guo ZW1; Zhang Y2; Lu WH2; Zhang C[*]2,4 |
| 刊名 | JOURNAL OF MOLECULAR NEUROSCIENCE
 |
| 出版日期 | 2013 |
| 卷号 | 51期号:2页码:474-477 |
| 关键词 | CACNA1C Association Polymorphism Schizophrenia |
| 通讯作者 | zhangchen645@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | The gene coding for the calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C) has been reported to be associated with bipolar disorder (BD) in our previous study. Broad evidence suggests some degree of shared genetic susceptibility between BD and schizophrenia. In this study, we aimed to determine whether the BD-associated gene CACNA1C confers susceptibility to schizophrenia. The association was assessed using a cross section study of 696 schizophrenia patients and 1,114 matched control subjects of Han Chinese origin. Between-group comparisons of genotypic or allelic frequencies showed no statistically significant differences. CACNA1C is unlikely to play a major role in the pathophysiology of schizophrenia in Han Chinese. Further large-scale replication studies using a haplotype-tagging single-nucleotide polymorphism selection approach are required to obtain more conclusive results of any potential association. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by National Natural Science Foundation of China (81000581), theChinaPostdoctoralScienceFoundation(2013M530410),theShanghai Science & Technology Development Foundation (12140904200), the 973 program from the Ministry of Science and Technology of China (2013CB835103), and the National Key Clinical Disciplines at Shanghai Mental Health Center (OMA-MH, 2011–873). |
| 语种 | 英语 |
| WOS记录号 | WOS:000324637200031 |
| 公开日期 | 2014-10-17 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8080]  |
| 专题 | 昆明动物研究所_分子病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.First Geriatric Department, Tongde Hospital of Zhejiang Province, Hangzhou 310012 Zhejiang, China 2.Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China 3.Department of Psychiatry, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, Chi 4.Key Laboratory of Animal Models andHuman Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Zhang JT,Cai J,Zhang X,et al. Does the Bipolar Disorder-Associated CACNA1C Gene Confer Susceptibility to Schizophrenia in Han Chinese?[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2013,51(2):474-477. |
| APA | Zhang JT.,Cai J.,Zhang X.,Ni JL.,Guo ZW.,...&Zhang C[*].(2013).Does the Bipolar Disorder-Associated CACNA1C Gene Confer Susceptibility to Schizophrenia in Han Chinese?.JOURNAL OF MOLECULAR NEUROSCIENCE,51(2),474-477. |
| MLA | Zhang JT,et al."Does the Bipolar Disorder-Associated CACNA1C Gene Confer Susceptibility to Schizophrenia in Han Chinese?".JOURNAL OF MOLECULAR NEUROSCIENCE 51.2(2013):474-477. |
入库方式： OAI收割
来源：昆明动物研究所
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