Association of genetic variation in CACNA1C with bipolar disorder in Han Chinese
文献类型：期刊论文
| 作者 | Zhang X1; Zhang C[*]2,3; Wu ZG2; Wang ZW2,4; Peng DH2; Chen J2; Hong W2; Yuan CM2; Li ZZ5; Yu SY6 |
| 刊名 | JOURNAL OF AFFECTIVE DISORDERS
 |
| 出版日期 | 2013 |
| 卷号 | 150期号:2页码:261-265 |
| 关键词 | Major depressive disorder Bipolar disorder CACNA1C Polymorphism Age at onset |
| 通讯作者 | zhangchen645@gmail.com ; yirufang@yahoo.com.cn |
| 合作状况 | 其它 |
| 英文摘要 | Background: A growing body of evidence highlights the existence of shared genetic susceptibility to both major depressive disorder (MDD) and bipolar disorder (BD), suggesting some potential genetic overlap between the disorders. Genome-wide association studies have identified consistent association of single nucleotide polymorphisms of the alpha-1 C subunit of the L-Lype voltage gated calcium channel gene (CACNA1C) with MDD and BD, suggesting CACNA1C as a promising candidate gene for susceptibility to mood disorders. In the present study, we tested the association of CACNA1C with MDD and BD in Han Chinese. Methods: We genotyped three potentially functional polymorphisms in 635 MDD patients, 286 BD patients and 730 normal, control patients. Results: The genotype frequencies of SNP rs1051375 showed statistically significant differences between the BD and control groups (P=0.005). At the allele level, the difference of G allele frequency of rs 105137 5 between BD patients and control subjects was also significant (P=0.011; OR=1.30, 95% CI: 1.06-1.58). We found that GG genotype of rs1051375 carriers had a lower age at onset than those with the AG or AA genotype, and the mean +/- standard deviation ages at onset of GG, AG and AA carriers were 24.04 +/- 4.22, 25.76 +/- 4.75 and 25.78 +/- 4.33 years, respectively. Neither genotype nor allele frequencies of the three polymorphisms were found to be significantly different between the MOD patients and control subjects. Limitations: The relative small sample size in BD group should be considered a limitation of this study. Conclusions: Our initial findings support a potential association of CACNA1C as a genetic risk factor for BD susceptibility. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China Nos. (30971047 and 81000581), Shanghai Science & Technology Development Fig. 1. Correlation between age at onset and CACNA1C rs1051375 polymorphism in BD patients. (A) Kaplan-Meier survival curves, describing lifetime distributions of age at onset in the patients been affected by BD (cumulative proportion of those remaining well until the first disease episode), as a function of CACNA1C rs1051375 polymorphism genotype (log rank statistic χ 2 ¼10.58, P¼0.005). The red line represents the GG genotype (n¼49), gray the AG genotype (n¼125), and green the AA genotype (n¼112). (B) Box plots showing median, interquartile values, and 10th and 90th percentiles (horizontal bar denotes the median). X. Zhang et al. / Journal of Affective Disorders 150 (2013) 261–265 264 Foundation (12140904200) and the National Key Clinical Disciplines at Shanghai Mental Health Center (OMA-MH2011-873). |
| 语种 | 英语 |
| WOS记录号 | WOS:000323563300013 |
| 公开日期 | 2014-10-22 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8128]  |
| 专题 | 昆明动物研究所_分子病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Department of Psychiatry, Tongji Hospital, Tongji University School of Medicine, Shanghai, China 2.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 4.Department of Psychiatry, Hongkou District Mental Health Center of Shanghai, Shanghai, China 5.Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China 6.Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China |
| 推荐引用方式 GB/T 7714 | Zhang X,Zhang C[*],Wu ZG,et al. Association of genetic variation in CACNA1C with bipolar disorder in Han Chinese[J]. JOURNAL OF AFFECTIVE DISORDERS,2013,150(2):261-265. |
| APA | Zhang X.,Zhang C[*].,Wu ZG.,Wang ZW.,Peng DH.,...&Fang YR[*].(2013).Association of genetic variation in CACNA1C with bipolar disorder in Han Chinese.JOURNAL OF AFFECTIVE DISORDERS,150(2),261-265. |
| MLA | Zhang X,et al."Association of genetic variation in CACNA1C with bipolar disorder in Han Chinese".JOURNAL OF AFFECTIVE DISORDERS 150.2(2013):261-265. |
入库方式： OAI收割
来源：昆明动物研究所
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