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Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism
文献类型：期刊论文
| 作者 | Zhang QY1; Liu J1; Liu B1; Xia J1; Chen NP1; Cao Y2; Zhang C2; Lu CJ1; Li MY[*]1; Zhu RZ[*]1 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2014 |
| 卷号 | 4期号:X页码:e4628 |
| 通讯作者 | Limingyi63@yahoo.cn |
| 合作状况 | 其它 |
| 英文摘要 | The development of antitumor chemotherapy drugs remains a key goal for oncologists, and natural products provide a vast resource for anti-cancer drug discovery. In the current study, we found that the flavonoid dihydromyricetin (DHM) exhibited antitumor activity against liver cancer cells, including primary cells obtained from hepatocellular carcinoma (HCC) patients. In contrast, DHM was not cytotoxic to immortalized normal liver cells. Furthermore, DHM treatment resulted in the growth inhibition and remission of xenotransplanted tumors in nude mice. Our results further demonstrated that this antitumor activity was caused by the activation of the p53-dependent apoptosis pathway via p53 phosphorylation at serine (15Ser). Moreover, our results showed that DHM plays a dual role in the induction of cell death when administered in combination with cisplatin, a common clinical drug that kills primary hepatoma cells but not normal liver cells. |
| 收录类别 | SCI |
| 资助信息 | The National Natural Science Funds (81041099) and Guangdong Province Natural Science Funds (S2011010003750) of China. |
| 语种 | 英语 |
| WOS记录号 | WOS:000334022500002 |
| 公开日期 | 2014-11-21 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8178]  |
| 专题 | 昆明动物研究所_分子病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Hepatic Disease, Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China 2.Laboratory of Molecular and Experimental Pathology, Key Laboratory of Animal Models and Human Disease Mechanisms of CAS and Yunnan Province,Kunming Institute of Zoology,Chines Academy of Sciences,Kunming, People’s Republic of China, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Zhang QY,Liu J,Liu B,et al. Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism[J]. SCIENTIFIC REPORTS,2014,4(X):e4628. |
| APA | Zhang QY.,Liu J.,Liu B.,Xia J.,Chen NP.,...&Zhu RZ[*].(2014).Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism.SCIENTIFIC REPORTS,4(X),e4628. |
| MLA | Zhang QY,et al."Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism".SCIENTIFIC REPORTS 4.X(2014):e4628. |
入库方式： OAI收割
来源：昆明动物研究所
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