Expression of MUC1 and CD176 (Thomsen-Friedenreich antigen) in Papillary Thyroid Carcinomas
文献类型：期刊论文
| 作者 | Zhan XX1; Zhao B1; Diao C1; Cao Y[*]2; Cheng RC[*]1 |
| 刊名 | ENDOCRINE PATHOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 26期号:1页码:21-26 |
| 关键词 | Papillary thyroid carcinomas MUC1 CD176 Thomsen-Friedenreich antigen Tumour-associated antigen Carrier molecule |
| 通讯作者 | caoy@mail.kiz.ac.cn ; cruochuan@foxmail.com |
| 合作状况 | 其它 |
| 英文摘要 | The incidence of thyroid cancer has appeared as an increasing trend globally, especially in Asian countries. In this study, the expression of mucin-1 (MUC1) and Thomsen-Friedenreich antigen, Gal beta 1-3GalNAc alpha 1-R (CD176) was investigated by immunohistochemistry in papillary thyroid carcinomas (PTCs), which accounts for approximately 80 % of all thyroid cancer. We found that 78 % of PTC overexpressed MUC1. Importantly, we observed firstly that CD176 was expressed in 63 % of PTC, but was faintly or not expressed in normal thyroid tissues and benign thyroid disease tissues, indicating that CD176 is also a tumour-associated antigen for PTCs. Moreover, expression of CD176 was strongly correlated with MUC1 by immunohistochemical staining in PTCs. Furthermore, we used the immunochemical method to confirm that MUC1 is a common and main carrier of CD176 in PTCs. Our data demonstrated that MUC1 and CD176 might be promising biomarkers for thyroid cancer. |
| 收录类别 | SCI |
| 资助信息 | This work was financially supported by the grants from National Natural Science Foundation of China (No. 81072563). |
| 语种 | 英语 |
| WOS记录号 | WOS:000350057500004 |
| 公开日期 | 2015-03-27 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8288]  |
| 专题 | 昆明动物研究所_分子病理学 |
| 作者单位 | 1.Thyroid Disease Diagnosis and Treatment Center, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming 650031, Yunnan, Chi 2.Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sci |
| 推荐引用方式 GB/T 7714 | Zhan XX,Zhao B,Diao C,et al. Expression of MUC1 and CD176 (Thomsen-Friedenreich antigen) in Papillary Thyroid Carcinomas[J]. ENDOCRINE PATHOLOGY,2015,26(1):21-26. |
| APA | Zhan XX,Zhao B,Diao C,Cao Y[*],&Cheng RC[*].(2015).Expression of MUC1 and CD176 (Thomsen-Friedenreich antigen) in Papillary Thyroid Carcinomas.ENDOCRINE PATHOLOGY,26(1),21-26. |
| MLA | Zhan XX,et al."Expression of MUC1 and CD176 (Thomsen-Friedenreich antigen) in Papillary Thyroid Carcinomas".ENDOCRINE PATHOLOGY 26.1(2015):21-26. |
入库方式： OAI收割
来源：昆明动物研究所
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