Down-regulation of microRNA-144 in air pollution-related lung cancer
文献类型：期刊论文
| 作者 | Pan HL1; Wen ZS2; Huang YC3; Cheng X1; Wang GZ1; Zhou YC3; Wang ZY4; Guo YQ4; Cao Y5; Zhou GB[*]1 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:X页码:e14331 |
| 通讯作者 | gbzhou@ioz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Air pollution has been classified as a group 1 carcinogen in humans, but the underlying tumourigenic mechanisms remain unclear. In Xuanwei city of Yunnan Province, the lung cancer incidence is among the highest in China, owing to severe air pollution generated by the combustion of smoky coal, providing a unique opportunity to dissect lung carcinogenesis. To identify abnormal miRNAs critical for air pollution-related tumourigenesis, we performed microRNA microarray analysis in 6 Xuanwei non-small cell lung cancers (NSCLCs) and 4 NSCLCs from control regions where smoky coal was not used. We found 13 down-regulated and 2 up-regulated miRNAs in Xuanwei NSCLCs. Among them, miR-144 was one of the most significantly down-regulated miRNAs. The expanded experiments showed that miR-144 was down-regulated in 45/51 (88.2%) Xuanwei NSCLCs and 34/54 (63%) control region NSCLCs (p = 0.016). MiR-144 interacted with the oncogene Zeb1 at 2 sites in its 3' untranslated region, and a decrease in miR-144 resulted in increased Zeb1 expression and an epithelial mesenchymal transition phenotype. Ectopic expression of miR-144 suppressed NSCLCs in vitro and in vivo by targeting Zeb1. These results indicate that down-regulation of miR-144 is critical for air pollution-related lung cancer, and the miR-144-Zeb1 signalling pathway could represent a potential therapeutic target. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Funds for Distinguished Young Scholar (81425025), National Key Programme for Basic Research (2012CB910800), National Natural Science Foundation of China (81171925, 81201537, U1202224, and 81460441), and grants from the State Key Laboratory of Medical Genomics. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9426]  |
| 专题 | 昆明动物研究所_分子病理学 |
| 作者单位 | 1.State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences & Graduate School of the University of Chinese Academy of Sciences, Beijing 100101 2.Department of Thoracic Surgery, the Cancer Hospital, Sun Yat-Sen University, Guangzhou 510060 3.Department of Thoracic Surgery, the Third Affiliated Hospital of Kunming Medical University (Yunnan Tumor Hospital), Kunming 650106, China 4.Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029 5.Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 6.Chinese Acad Sci, Kunming Inst Zool, Lab Mol & Expt Pathol, Kunming 650223, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan HL,Wen ZS,Huang YC,et al. Down-regulation of microRNA-144 in air pollution-related lung cancer[J]. SCIENTIFIC REPORTS,2015,5(X):e14331. |
| APA | Pan HL.,Wen ZS.,Huang YC.,Cheng X.,Wang GZ.,...&Zhou GB[*].(2015).Down-regulation of microRNA-144 in air pollution-related lung cancer.SCIENTIFIC REPORTS,5(X),e14331. |
| MLA | Pan HL,et al."Down-regulation of microRNA-144 in air pollution-related lung cancer".SCIENTIFIC REPORTS 5.X(2015):e14331. |
入库方式： OAI收割
来源：昆明动物研究所
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