Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer.
文献类型：期刊论文
| 作者 | Yu XJ1,12; Yang MJ2; Zhou B1; Wang GZ1; Wu LC3; Cheng X1; Wen ZS4; Huang JY5; Zhang YD6; Gao XH1 |
| 刊名 | EBioMedicine
 |
| 出版日期 | 2015 |
| 卷号 | 2期号:6页码:583-590 |
| 关键词 | Air pollution Exome sequencing Exposure Lung cancer Whole genome sequencing |
| 通讯作者 | gbzhou@ioz.ac.cn ; wangsy@chgc.sh.cn ; caoy@mail.kiz.ac.cn ; sjchen@stn.sh.cn |
| 英文摘要 | Air pollution has been classified as Group 1 carcinogenic to humans, but the underlying tumorigenesis remains unclear. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China attributed to severe air pollution generated by combustion of smoky coal, providing a unique opportunity to dissect lung carcinogenesis of air pollution. Here we analyzed the somatic mutations of 164 non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used. Whole genome sequencing revealed a mean of 289 somatic exonic mutations per tumor and the frequent C:G → A:T nucleotide substitutions in Xuanwei NSCLCs. Exome sequencing of 2010 genes showed that Xuanwei and CR NSCLCs had a mean of 68 and 22 mutated genes per tumor, respectively (p < 0.0001). We found 167 genes (including TP53, RYR2, KRAS, CACNA1E) which had significantly higher mutation frequencies in Xuanwei than CR patients, and mutations in most genes in Xuanwei NSCLCs differed from those in CR cases. The mutation rates of 70 genes (e.g., RYR2, MYH3, GPR144, CACNA1E) were associated with patients' lifetime benzo(a)pyrene exposure. This study uncovers the mutation spectrum of air pollution-related lung cancers, and provides evidence for pollution exposure-genomic mutation relationship at a large scale. |
| 收录类别 | SCI |
| 资助信息 | This project has been funded by the National Natural Science Funds for Distinguished Young Scholar to G.B.Z. (81425025), National Key Program for Basic Research (2012CB910800), National Natural Science Foundation of China (81171925, 81201537), and grant from the Shang- hai Municipal Science and Technology Commission (13431902000). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9451]  |
| 专题 | 昆明动物研究所_分子病理学 |
| 作者单位 | 1.State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences & University of Chinese Academy of Sciences, Beijing 100101, China 2.The Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center, Shanghai 201203, China 3.Department of Thoracic Surgery, Yunnan Cancer Hospital, Kunming 650106, China 4.Department of Thoracic Surgery, The Cancer Hospital, Sun Yat-Sen University, Guangzhou 510060, China 5.State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University (SJTU) School of Medicine, and Shanghai Center for Systems Biomedicine, SJTU, Shanghai 200025, China 6.Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 7.Department of Thoracic Surgery, The First People's Hospital of Yunnan Province, Kunming 650032, China 8.Department of Pathology, The First People's Hospital of Qu Jing City, Qu Jing 655000, Yunnan Province, China 9.Department of Thoracic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China 10.Department of Pathology, Rui Jin Hospital Affiliated to SJTU School of Medicine, Shanghai 200025, China |
| 推荐引用方式 GB/T 7714 | Yu XJ,Yang MJ,Zhou B,et al. Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer.[J]. EBioMedicine,2015,2(6):583-590. |
| APA | Yu XJ.,Yang MJ.,Zhou B.,Wang GZ.,Wu LC.,...&Zhou GB[*].(2015).Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer..EBioMedicine,2(6),583-590. |
| MLA | Yu XJ,et al."Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer.".EBioMedicine 2.6(2015):583-590. |
入库方式： OAI收割
来源：昆明动物研究所
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