Reactivity of a humanized antibody (hPankoMab) towards a tumor-related MUC1 epitope (TA-MUC1) with various human carcinomas
文献类型：期刊论文
| 作者 | Fan XN1; Karsten U2; Goletz S[*]2; Cao Y[*]1 |
| 刊名 | PATHOLOGY RESEARCH AND PRACTICE
 |
| 出版日期 | 2010 |
| 卷号 | 206期号:8页码:585-589 |
| 关键词 | Humanized antibody PankoMab MUC1 Carcinoma In vivo |
| 通讯作者 | steffen.goletz@glycotope.com ; caoy@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Humanized antibodies against tumor-related antigens are now established reagents for in vivo diagnostics and for therapeutic approaches, and are increasingly developed. Humanized PankoMab (hPankoMab), a humanized form of PankoMab directed against a novel tumor-related MUC1 epitope (TA-MUC1), was recently developed for clinical application. In the present study, the reactivity of hPankoMab with various human cancers was systematically studied by immunohistochemistry on 137 surgical specimens, including lung, breast, gastric, colorectal, liver, cervical, kidney, thyroid, and other carcinomas, as well as on several non-epithelial malignancies. The study was performed on paraffin sections without antigen retrieval. hPankoMab reacted strongly with carcinomas originating from glandular or squamous epithelia, weakly with hepatocellular carcinomas, and not with sarcomas. The binding sites of hPankoMab in carcinomas were found around the whole cell surface and, in most cases, also in the cytoplasm of cancer cells. |
| 收录类别 | SCI |
| 资助信息 | This research was partly supported by the Kunming Institute of Zoology, Chinese Academy of Sciences (to Xiao-Na Fan). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9614]  |
| 专题 | 昆明动物研究所_分子病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, Yunnan 650223, China 2.Glycotope GmbH, Robert-Roessle-Str. 10, 13125 Berlin-Buch, Germany |
| 推荐引用方式 GB/T 7714 | Fan XN,Karsten U,Goletz S[*],et al. Reactivity of a humanized antibody (hPankoMab) towards a tumor-related MUC1 epitope (TA-MUC1) with various human carcinomas[J]. PATHOLOGY RESEARCH AND PRACTICE,2010,206(8):585-589. |
| APA | Fan XN,Karsten U,Goletz S[*],&Cao Y[*].(2010).Reactivity of a humanized antibody (hPankoMab) towards a tumor-related MUC1 epitope (TA-MUC1) with various human carcinomas.PATHOLOGY RESEARCH AND PRACTICE,206(8),585-589. |
| MLA | Fan XN,et al."Reactivity of a humanized antibody (hPankoMab) towards a tumor-related MUC1 epitope (TA-MUC1) with various human carcinomas".PATHOLOGY RESEARCH AND PRACTICE 206.8(2010):585-589. |
入库方式： OAI收割
来源：昆明动物研究所
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