Alteration of adhesion molecule expression and cellular polarity in hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Cao Y[*]1; Chang H1; Li L2; Cheng RC3; Fan XN1 |
| 刊名 | HISTOPATHOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 51期号:4页码:528-538 |
| 关键词 | adherens junctions desmosomes liver tight junction tumour |
| 通讯作者 | caoy@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Aims: To study the expression of adhesion molecules in human liver and their possible roles during hepatocarcinogenesis. Methods and results: The expression of adhesion molecules in normal liver tissues, benign including probable premalignant lesions and malignant lesions was systematically investigated by immunohistochemistry and Western blotting. In normal liver, both hepatocytes and bile duct cells expressed symplekin, desmoglein 1/2, desmocollin 2, desmoplakin and plakophilin 2, but did not express desmocollin 1/3 or plakophilin 1. In benign hepatocyte lesions, expression of the adherens junctions and desmosomes was uniform and slightly increased, but symplekin appeared to show reduced expression in dysplastic lesions. In hepatocellular carcinoma (HCC), the expression of adhesion molecules was often heterogeneous and of abnormal location. Tumour cells with an abnormal distribution or loss of adhesion molecules showed an apolar arrangement of tissue architecture. The expression levels of the adhesion molecules correlated with the differentiation grades of HCC cells. Conclusions: The decreased expression of symplekin may be an early step in the transformation of hepatocytes, whereas alteration of the expression of adherens junctions and desmosomes may indicate more serious changes. |
| 收录类别 | SCI |
| 资助信息 | Part of this work was carried out in the German Cancer Research Centre, Heidelberg, Germany. We especially thank Professor (Dr) Peter Bannasch (German Cancer Research Centre, Heidelberg, Germany) for his sup- port. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9632]  |
| 专题 | 昆明动物研究所_分子病理学 |
| 作者单位 | 1.Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan 2.Department of General Surgery, Kunming First People Hospital, Kunming 3.Department of General Surgery, First Affiliated Hospital of Kunming Medical College, Kunming, China |
| 推荐引用方式 GB/T 7714 | Cao Y[*],Chang H,Li L,et al. Alteration of adhesion molecule expression and cellular polarity in hepatocellular carcinoma[J]. HISTOPATHOLOGY,2007,51(4):528-538. |
| APA | Cao Y[*],Chang H,Li L,Cheng RC,&Fan XN.(2007).Alteration of adhesion molecule expression and cellular polarity in hepatocellular carcinoma.HISTOPATHOLOGY,51(4),528-538. |
| MLA | Cao Y[*],et al."Alteration of adhesion molecule expression and cellular polarity in hepatocellular carcinoma".HISTOPATHOLOGY 51.4(2007):528-538. |
入库方式： OAI收割
来源：昆明动物研究所
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