Pitfalls in the analysis of ancient human mtDNA
文献类型：期刊论文
| 作者 | Yao YG1,3; Zhang YP[*]1,2 |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2003 |
| 卷号 | 48期号:8页码:826-830 |
| 关键词 | ancient DNA mtDNA phylogeny pitfall Silk Road |
| ISSN号 | 1001-6538 |
| 通讯作者 | zhangyp1@263.net.cn |
| 合作状况 | 其它 |
| 英文摘要 | The retrieval of DNA from ancient human specimens is not always successful owing to DNA deterioration and contamination although it is vital to provide new insights into the genetic structure of ancient people and to reconstruct the past history. Normally, only short DNA fragments can be retrieved from the ancient specimens. How to identify the authenticity of DNA obtained and to uncover the information it contained are difficult. We employed the ancient mtDNAs reported from Central Asia (including Xinjiang, China) as an example to discern potentially extraneous DNA contamination based on the updated mtDNA phylogeny derived from mtDNA control region, coding region, as well as complete sequence information. Our results demonstrated that many mtDNAs reported are more or less problematic. Starting from a reliable mtDNA phylogeney and combining the available modern data into analysis, one can ascertain the authenticity of the ancient DNA, distinguish the potential errors in a data set, and efficiently decipher the meager information it harbored. The reappraisal of the mtDNAs with the age of more than 2000 years from Central Asia gave support to the suggestion of extensively (pre)historical gene admixture in this region. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (Grant No. 30024004), the Fund of the Chinese Academy of Sciences (Grant No. KSCX2-SW-2010), and the Natural Science Foundation of Yunnan Province (Grant No. 2000C0077M). |
| 原文出处 | 200348826.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2651]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_分子进化基因组学 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Laboratory of Molecular Evolution and Genome Diversity, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University,Kunming 650091, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Yao YG,Zhang YP[*]. Pitfalls in the analysis of ancient human mtDNA[J]. CHINESE SCIENCE BULLETIN,2003,48(8):826-830. |
| APA | Yao YG,&Zhang YP[*].(2003).Pitfalls in the analysis of ancient human mtDNA.CHINESE SCIENCE BULLETIN,48(8),826-830. |
| MLA | Yao YG,et al."Pitfalls in the analysis of ancient human mtDNA".CHINESE SCIENCE BULLETIN 48.8(2003):826-830. |
入库方式： OAI收割
来源：昆明动物研究所
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