Structure analysis of CCR5 from human and primates
文献类型：期刊论文
| 作者 | Yang J; Zhang YW; Huang JF; Zhang YP; Liu CQ[*] |
| 刊名 | JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
 |
| 出版日期 | 2000 |
| 卷号 | 505期号:X页码:199-210 |
| 关键词 | human CCR5 primate CCR5 molecular modeling evolution |
| ISSN号 | 0166-1280 |
| 通讯作者 | jieyang3@hotmail.com |
| 合作状况 | 其它 |
| 英文摘要 | It is well known that the chemokine receptor CCR5 plays very important roles in HIV-1 virus infection. A three-dimensional molecular model of human CCR5 was generated by SYBYL, a distance geometry-based homologous modeling package, using the corresponding transmembrane domain of bacteriorhodopsin as the template. On the basis of human CCR5 model, we also built 18 3D molecular models of CCR5 in primates from Pongo pygmaeus, Pygathrix nemaeus, Macaca assameniss, Trachy-pithecus phayrei, T. francoisi, M. arotoides, Rhinopithecus roxellance, R, bieti, R. avunculus, Hylobates leucogenys, Pan troglodytes, Gorilla gorilla, Cercopithecus aethiops 1, C. aethiops 2, Papio hamadryas M. mulatta, M. fascicularis and M. nemestrina. Structural analyses and statistics results suggested that the main-chains of the primate CCR5 were similar to that of the human CCR5 and that the fit-RMS deviation values of these primate CCR5 were less than 0.1 Angstrom. Moreover, the structures of these CCR5 proteins, except those of the African green monkey 1 (C.aet1), do not have a remarkable difference. It is proved that the 14th residue is possibly very important in the inhibition infections by M-tropic HIV-1, and it is also demonstrated that the 13th residue of human CCR5 was changed from asparagine into aspartic acid in all these primates. It means that the primate CCR5 no longer depend on CD4 for efficient entry, but human CCR5 may have evolved subsequently due to the use of CD4 as a receptor, allowing the high-affinity chemokine receptor-binding site of HIV to be sequestered from host immune surveillance. |
| 收录类别 | SCI |
| 资助信息 | This work is supported by NSFC (Nature Science Fund of China, No. 39770418, and No. 39730310) and Chinese Academy of Sciences. |
| 原文出处 | 2000505199.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/3971]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_结构生物信息学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming YN650223, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Yang J,Zhang YW,Huang JF,et al. Structure analysis of CCR5 from human and primates[J]. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM,2000,505(X):199-210. |
| APA | Yang J,Zhang YW,Huang JF,Zhang YP,&Liu CQ[*].(2000).Structure analysis of CCR5 from human and primates.JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM,505(X),199-210. |
| MLA | Yang J,et al."Structure analysis of CCR5 from human and primates".JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM 505.X(2000):199-210. |
入库方式： OAI收割
来源：昆明动物研究所
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