Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention
文献类型：期刊论文
| 作者 | Swanson J[*]1; Oosterlaan J4; Murias M1; Schuck S1; Flodman P1; Spence MA1; Wasdell M1; Ding YC2,9; Chi HC2; Smith M1 |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2000 |
| 卷号 | 97期号:9页码:4754-4759 |
| ISSN号 | 0027-8424 |
| 通讯作者 | jmswanso@uci.edu. |
| 合作状况 | 其它 |
| 英文摘要 | An association of the dopamine receptor D4 (DRD4) gene located on chromosome 11p15.5 and attention deficit/hyperactivity disorder (ADHD) has been demonstrated and replicated by multiple investigators. A specific allele [the 7-repeat of a 48-bp variable number of tandem repeats (VNTR) in exon 3] has been proposed as an etiological factor in attentional deficits manifested in some children diagnosed with this disorder. In the current study, we evaluated ADHD subgroups defined by the presence or absence of the 7-repeat allele of the DRD4 gene, using neuropsychological tests with reaction time measures designed to probe attentional networks with neuroanatomical foci in D4-rich brain regions. Despite the same severity of symptoms on parent and teacher ratings for the ADHD subgroups, the average reaction times of the 7-present subgroup showed normal speed and variability of response whereas the average reaction times of the 7-absent subgroup showed the expected abnormalities (slow and variable responses). This was opposite the primary prediction of the study. The 7-present subgroup seemed to be free of some of the neuropsychological abnormalities thought to characterize ADHD. |
| 收录类别 | SCI |
| 原文出处 | 2000974754.pdf |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/3979]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Department of Pediatrics, University of California, Irvine, CA 92612 2.Departments of Biological Chemistry,University of California, Irvine, CA 92697 3.Psychology and Social Behavior, University of California, Irvine, CA 92697 4.Department of Clinical Neuropsychology, Free University, Amsterdam, De Boelelaan 1109 1081 HV Amsterdam, The Netherlands 5.The Sackler Institute for Developmental Psychobiology, Department of Psychiatry, Joan and Sanford I. Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10021 6.Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada M5T 1R8 7.Department of Psychology, University of Texas, Mezes 330, Austin, TX 78712 8.Department of Psychology, Chinese University of Hong Kong, 3yF, Sino Building, Shatin, New Territories of Hong Kong 9.Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People’s Republic of China 10.Department of Psychology, University of Tel Aviv, Ramat Aviv, Tel Aviv 69978, Israel |
| 推荐引用方式 GB/T 7714 | Swanson J[*],Oosterlaan J,Murias M,et al. Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2000,97(9):4754-4759. |
| APA | Swanson J[*].,Oosterlaan J.,Murias M.,Schuck S.,Flodman P.,...&Sadeh A.(2000).Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,97(9),4754-4759. |
| MLA | Swanson J[*],et al."Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97.9(2000):4754-4759. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。