Molecular basis of albinism in the rhesus monkey
文献类型：期刊论文
| 作者 | Ding B1; Ryder OA2; Wang XX1; Bai SC1; Zhou SQ1; Zhang YP[*]1 |
| 刊名 | MUTATION RESEARCH
 |
| 出版日期 | 2000 |
| 卷号 | 449期号:1-2页码:1-6 |
| 关键词 | Rhesus monkey Oculocutaneous albinism Tyrosinase Mutation |
| ISSN号 | 0027-5107 |
| 通讯作者 | zhangyp@public.km.yn.ac |
| 合作状况 | 其它 |
| 英文摘要 | Sequence analysis of the tyrosinase (TYR) coding region from one albino rhesus monkey (Macaca mulatta) family revealed that the two monkeys with phenotype similar to human TYR-negative oculocutaneous albinism (OCA) were homozygous for a missense mutation (S184TER) in exon 1 at codon 184. The offspring of one of the albino monkey (''Kangkang'') are all heterozygous for the S184TER mutation, but the S184TER mutation was not observed in 93 control individuals. We conclude that the point mutation is responsible and sufficient to generate the albino rhesus monkey phenotype. The rough age of the S184TER nonsense mutation may be about 0.8 million years using a rate of 0.16% per million years. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. |
| 原文出处 | 20004491.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/3987]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Laboratory of Cellular and Molecular EÕolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China 2.Zoological Society of San Diego, San Diego, CA 92112, USA |
| 推荐引用方式 GB/T 7714 | Ding B,Ryder OA,Wang XX,et al. Molecular basis of albinism in the rhesus monkey[J]. MUTATION RESEARCH,2000,449(1-2):1-6. |
| APA | Ding B,Ryder OA,Wang XX,Bai SC,Zhou SQ,&Zhang YP[*].(2000).Molecular basis of albinism in the rhesus monkey.MUTATION RESEARCH,449(1-2),1-6. |
| MLA | Ding B,et al."Molecular basis of albinism in the rhesus monkey".MUTATION RESEARCH 449.1-2(2000):1-6. |
入库方式： OAI收割
来源：昆明动物研究所
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