Melanocortin-1 receptor gene variants in four Chinese ethnic populations
文献类型：期刊论文
| 作者 | Shi P; Lu XM; Luo HR; Xiang-Yu JG; Zhang YP[*] |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2001 |
| 卷号 | 11期号:1页码:81-84 |
| 关键词 | MC1R gene ethnic populations nonsynonymous site synonymous site |
| ISSN号 | 1001-0602 |
| 通讯作者 | zhangyp@public.km.yn.cn |
| 英文摘要 | There is strong relationship between melanocortin-1 receptor (MC1R) gene variants and human hair color and skin type. Based on a sequencing study of MC1R gene in 50 individuals from the Uygur, Tibetan, Wa and Dai ethnic populations, we discuss the occurrence of 7 mc1r variants consisting of 5 nonsynonymous sites (Val60Leu, Arg67Gln, Val92Met, Arg163Gln and Ala299Val) and 2 synonymous sites (C414T and A942G), among which C414T and Ala299Val were reported for the first time. Confirmation and analysis were also made of 122 individuals at three common point mutations (Val92Met, Arg163Gln, A942G) using PCR-SSCP. The frequency of Arg163Gln variant varies in the four ethnic populations, with percentage of 40%, 85.0%, 66.2% and 72.7%, respectively, while those of Val92Met and A942G are roughly similar in these four populations. The different environments, migration and admixture of various ethnic groups in China might have impact on the observed frequency of Arg163Gln. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Natural Sciences Foundation of China, the Chinese Academy of Sciences and NSF of Yunnan Province to Ya Ping ZHANG. |
| 原文出处 | 20011181.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4025]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_进化与功能基因组学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Shi P,Lu XM,Luo HR,et al. Melanocortin-1 receptor gene variants in four Chinese ethnic populations[J]. CELL RESEARCH,2001,11(1):81-84. |
| APA | Shi P,Lu XM,Luo HR,Xiang-Yu JG,&Zhang YP[*].(2001).Melanocortin-1 receptor gene variants in four Chinese ethnic populations.CELL RESEARCH,11(1),81-84. |
| MLA | Shi P,et al."Melanocortin-1 receptor gene variants in four Chinese ethnic populations".CELL RESEARCH 11.1(2001):81-84. |
入库方式： OAI收割
来源：昆明动物研究所
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