Phylogeographic differentiation of mitochondrial DNA in Han Chinese
文献类型：期刊论文
| 作者 | Yao YG1; Kong QP1; Bandelt HJ2; Kivisild T3; Zhang YP[*]1 |
| 刊名 | AMERICAN JOURNAL OF HUMAN GENETICS
 |
| 出版日期 | 2002 |
| 卷号 | 70期号:3页码:635-651 |
| ISSN号 | 0002-9297 |
| 通讯作者 | zhangyp@public.km.yn.cn |
| 合作状况 | 其它 |
| 英文摘要 | To characterize the mitochondrial DNA (mtDNA) variation in Han Chinese from several provinces of China, we have sequenced the two hypervariable segments of the control region and the segment spanning nucleotide positions 10171-10659 of the coding region, and we have identified a number of specific coding-region mutations by direct sequencing or restriction-fragment-length-polymorphism tests. This allows us to define new haplogroups (clades of the mtDNA phylogeny) and to dissect the Han mtDNA pool on a phylogenetic basis, which is a prerequisite for any fine-grained phylogeographic analysis, the interpretation of ancient mtDNA, or future complete mtDNA sequencing efforts. Some of the haplogroups under study differ considerably in frequencies across different provinces. The southernmost provinces show more pronounced contrasts in their regional Han mtDNA pools than the central and northern provinces. These and other features of the geographical distribution of the mtDNA haplogroups observed in the Han Chinese make an initial Paleolithic colonization from south to north plausible but would suggest subsequent migration events in China that mainly proceeded from north to south and east to west. Lumping together all regional Han mtDNA pools into one fictive general mtDNA pool or choosing one or two regional Han populations to represent all Han Chinese is inappropriate for prehistoric considerations as well as for forensic purposes or medical disease studies. |
| 收录类别 | SCI |
| 资助信息 | This research was supported by grants from the Natural Sciences Foundation of China, the Chinese Academy of Sciences, and the Natural Sciences Foundation of Yunnan Province, as well as by a short-term research scholarship from the German Deutchser Akademischer Austauschdienst. |
| 原文出处 | 200270635.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4069]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_分子人类学 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Laboratory of Molecular Evolution and Genome Diversity, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Fachbereich Mathematik, Universita ¨t Hamburg, Hamburg 3.Department of Evolutional Biology, Institute of Molecular and Cell Biology, Tartu University and Estonian Biocentre, Tartu, Estonia |
| 推荐引用方式 GB/T 7714 | Yao YG,Kong QP,Bandelt HJ,et al. Phylogeographic differentiation of mitochondrial DNA in Han Chinese[J]. AMERICAN JOURNAL OF HUMAN GENETICS,2002,70(3):635-651. |
| APA | Yao YG,Kong QP,Bandelt HJ,Kivisild T,&Zhang YP[*].(2002).Phylogeographic differentiation of mitochondrial DNA in Han Chinese.AMERICAN JOURNAL OF HUMAN GENETICS,70(3),635-651. |
| MLA | Yao YG,et al."Phylogeographic differentiation of mitochondrial DNA in Han Chinese".AMERICAN JOURNAL OF HUMAN GENETICS 70.3(2002):635-651. |
入库方式： OAI收割
来源：昆明动物研究所
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