Identification of native American founder mtDNAs through the analysis of complete mtDNA sequences: Some caveats
文献类型：期刊论文
| 作者 | Bandelt HJ[*]1; Herrnstadt C2; Yao YG3; Kong QP3; Kivisild T4,5; Rengo C6; Scozzari R7; Richards M8; Villems R4; Macaulay V9 |
| 刊名 | ANNALS OF HUMAN GENETICS
 |
| 出版日期 | 2003 |
| 卷号 | 67期号:X页码:512-524 |
| ISSN号 | 0003-4800 |
| 通讯作者 | bandelt@math. uni-hamburg.de |
| 合作状况 | 其它 |
| 英文摘要 | In this study, a detailed analysis of both previously published and new data was performed to determine whether complete, or almost complete, mtDNA sequences can resolve the long-debated issue of which Asian mtDNAs were founder sequences for the Native American mtDNA pool. Unfortunately, we now know that coding region data and their analysis are not without problems. To obtain and report reasonably correct sequences does not seem to be a trivial task, and to discriminate between Asian-and Native American mtDNA ancestries may be more complex than previously believed. It is essential to take into account the effects of mutational hot spots in both the control and coding regions, so that the number of apparent Native American mtDNA founder sequences is not erroneously inflated. As we report here, a careful analysis of all available data indicates that there is very little evidence that more than five founder mtDNA sequences entered Beringia before the Last Glacial Maximum and left their traces in the current Native American mtDNA pool. |
| 收录类别 | SCI |
| 资助信息 | Y-GY, Q-PK, and Y-PZ are supported by the Natu- ral Sciences Foundation of Yunnan Province and Natu- ral Sciences Foundation of China (NSFC); VM is a Well- come Trust Research Career Development Fellow; NH acknowledges research support from the National Sci- ence Foundation; AT received support from Telethon- Italy E.0890, the Italian Ministry of the University (Progetti Ricerca Interesse Nazionale 2002) and Progetto CNR-MIUR Genomica Funzionale-Legge 449/97. |
| 原文出处 | 200367512.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4073]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_分子人类学 昆明动物研究所_重大疾病机理的遗传学 |
| 作者单位 | 1.Fachbereich Mathematik, Universität Hamburg, Hamburg, Germany 2.MitoKor, San Diego, California, USA 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 4.Department of Evolutionary Biology, Tartu University and Estonian Biocentre, Tartu, Estonia 5.Department of Genetics, Stanford University, Stanford, California, USA 6.Istituto di Medicina Legale, Università Cattolica del Sacro Cuore, Rome, Italy 7.Dipartimento di Genetica e Biologia Molecolare, Università “La Sapienza”, Rome, Italy 8.Department of Chemical and Biological Sciences, University of Huddersfield, Huddersfield, UK 9.Department of Statistics, University of Oxford, Oxford, UK 10.Department of Radiation Oncology, University of Texas Medical Branch, Galveston, Texas, USA |
| 推荐引用方式 GB/T 7714 | Bandelt HJ[*],Herrnstadt C,Yao YG,et al. Identification of native American founder mtDNAs through the analysis of complete mtDNA sequences: Some caveats[J]. ANNALS OF HUMAN GENETICS,2003,67(X):512-524. |
| APA | Bandelt HJ[*].,Herrnstadt C.,Yao YG.,Kong QP.,Kivisild T.,...&Zhang YP.(2003).Identification of native American founder mtDNAs through the analysis of complete mtDNA sequences: Some caveats.ANNALS OF HUMAN GENETICS,67(X),512-524. |
| MLA | Bandelt HJ[*],et al."Identification of native American founder mtDNAs through the analysis of complete mtDNA sequences: Some caveats".ANNALS OF HUMAN GENETICS 67.X(2003):512-524. |
入库方式： OAI收割
来源：昆明动物研究所
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