Intra- and interspecific variation of the CCR5 gene in higher primates
文献类型：期刊论文
| 作者 | Zhang YW1; Ryder OA[*]1; Zhang YP2,3 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2003 |
| 卷号 | 20期号:10页码:1722-1729 |
| ISSN号 | 0737-4038 |
| 关键词 | CCR5 evolution primates |
| 通讯作者 | oryder@ucsd.edu |
| 合作状况 | 其它 |
| 英文摘要 | We have evaluated the molecular evolution of the chemokine receptor CCR5 in primates. The chemokine receptor CCR5 serves as a major co-receptor for human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infection. Knowledge of evolution of the CCR5 molecule and selection on the CCR5 gene may shed light on its functional role. The comparison of differences between intraspecific polymorphisms and interspecific fixed substitutions provides useful information regarding modes of selection during the course of evolution. There is marked polymorphism in the CCR5 gene sequence within different primate species, whereas sequence divergence between different species is small. By using contingency tests, we compared synonymous (SS) and nonsynonymous (NS) CCR5 mutations occurring within and between a broad range of primates. Our results demonstrate that CCR5 evolution did not follow expectations, of strict neutrality at the level of the whole gene. The proportion of NS to SS at the intraspecific level was significantly higher than that observed at the interspecific level. These results suggest that most CCR5 NS polymorphisms are slightly deleterious. However, at domains more closely correlated with its known biological functions, there was no obvious evidence to support deviation from neutrality. |
| 资助信息 | This work was supported by the Alice B. Tyler Perpetual Trust (Y.W.Z. and O.A.R.), the Chinese Academy of Sciences, and the Natural Science Foundation of China (Y.W.Z. and Y.P.Z.). |
| 收录类别 | SCI |
| 原文出处 | 2003201722.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4081]  |
| 专题 | 昆明动物研究所_分子进化基因组学 |
| 作者单位 | 1.Center for Reproduction of Endangered Species, Zoological Society of San Diego, San Diego, California 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 3.Laboratory of Molecular Genetics, Yunnan University, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Zhang YW,Ryder OA[*],Zhang YP. Intra- and interspecific variation of the CCR5 gene in higher primates[J]. MOLECULAR BIOLOGY AND EVOLUTION,2003,20(10):1722-1729. |
| APA | Zhang YW,Ryder OA[*],&Zhang YP.(2003).Intra- and interspecific variation of the CCR5 gene in higher primates.MOLECULAR BIOLOGY AND EVOLUTION,20(10),1722-1729. |
| MLA | Zhang YW,et al."Intra- and interspecific variation of the CCR5 gene in higher primates".MOLECULAR BIOLOGY AND EVOLUTION 20.10(2003):1722-1729. |
入库方式： OAI收割
来源：昆明动物研究所
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