Adaptive diversification of bitter taste receptor genes in mammalian evolution
文献类型：期刊论文
| 作者 | Shi P1,2; Zhang JZ3; Yang H1,2; Zhang YP[*]1,4 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2003 |
| 卷号 | 20期号:5页码:805-814 |
| 关键词 | evolution bitter taste receptor positive selection gene duplication |
| ISSN号 | 0737-4038 |
| 通讯作者 | zhangyp1@263.net.cn |
| 合作状况 | 其它 |
| 英文摘要 | The diversity and evolution of bitter taste perception in mammals is not well understood. Recent discoveries of bitter taste receptor (T2R) genes provide an opportunity for a genetic approach to this question. We here report the identification of 10 and 30 putative T2R genes from the draft human and mouse genome sequences, respectively, in addition to the 23 and 6 previously known T2R genes from the two species. A phylogenetic analysis of the T2R genes suggests that they can be classified into three main groups, which are designated A, B, and C. Interestingly, while the one-to-one gene orthology between the human and mouse is common to group B and C genes, group A genes show a pattern of species- or lineage-specific duplication. It is possible that group B and C genes are necessary for detecting bitter tastants common to both humans and mice, whereas group A genes are used for species-specific bitter tastants. The analysis also reveals that phylogenetically closely related T2R genes are close in their chromosomal locations, demonstrating tandem gene duplication as the primary source of new T2Rs. For closely related paralogous genes, a rate of nonsynonymous nucleotide substitution significantly higher than the rate of synonymous substitution was observed in the extracellular regions of T2Rs, which are presumably involved in tastant-binding. This suggests the role of positive selection in the diversification of newly duplicated T2R genes. Because many natural poisonous substances are bitter, we conjecture that the mammalian T2R genes are under diversifying selection for the ability to recognize a diverse array of poisons that the organisms may encounter in exploring new habitats and diets. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the Chinese Academy of Sciences (KSCX2-1–05), Program for Key International S & T Cooperation Project of the People’s Republic of China (2001CB711103), and National Natural Science Foundation of China to Y.P.Z., and by a start-up fund from the University of Michigan to J.Z. |
| 原文出处 | 200320805.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4095]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_进化与功能基因组学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Laboratory of Molecular Evolution and Genome Diversity, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.The Graduate School, Chinese Academy of Sciences, Beijing, China 3.Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109 4.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China |
| 推荐引用方式 GB/T 7714 | Shi P,Zhang JZ,Yang H,et al. Adaptive diversification of bitter taste receptor genes in mammalian evolution[J]. MOLECULAR BIOLOGY AND EVOLUTION,2003,20(5):805-814. |
| APA | Shi P,Zhang JZ,Yang H,&Zhang YP[*].(2003).Adaptive diversification of bitter taste receptor genes in mammalian evolution.MOLECULAR BIOLOGY AND EVOLUTION,20(5),805-814. |
| MLA | Shi P,et al."Adaptive diversification of bitter taste receptor genes in mammalian evolution".MOLECULAR BIOLOGY AND EVOLUTION 20.5(2003):805-814. |
入库方式： OAI收割
来源：昆明动物研究所
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