Evolution of the DRD2 gene haplotype and its association with alcoholism in Mexican Americans
文献类型：期刊论文
| 作者 | Luo HR1; Hou ZF2; Wu JL1; Zhang YP2,3; Wan YJY[*]1 |
| 刊名 | ALCOHOL
 |
| 出版日期 | 2005 |
| 卷号 | 36期号:2页码:117-125 |
| 关键词 | D2 dopamine receptor DRD2 haplotype SNP genotype alcoholism Mexican Americans |
| ISSN号 | 0741-8329 |
| 通讯作者 | ywan@kumc.edu |
| 合作状况 | 其它 |
| 英文摘要 | The human D2 dopamine receptor gene (DRD2) plays a central role in the neuromodulation of appetitive behaviors and is implicated in having a possible role in susceptibility to alcoholism. We genotyped an SNP in DRD2 Exon 8 in 251 nonalcoholic, unrelated, healthy controls and 200 alcoholic Mexican Americans. The DRD2 haplotypes were analyzed using the Exon 8 genotype in combination with five other SNP genotypes, which were obtained from our previous study. The ancestral origins of the DRD2 polymorphisms have been determined by sequencing the homologous region in other higher primates. Twenty DRD2 haplotypes, defined as H1 to H20 based on their frequency from high to low, were obtained in this major minority population. The ancestral haplotype "I-132-G-C-G-A1" and two one-step mutation haplotypes were absent in our study population. The haplotype H1, "I-B1-T-C-A-A1", with the highest frequency in the population, is a three-step mutation from the ancestral form. The first five or eight major haplotypes make up 87% or 95% of the entire population, respectively. The prevalence of the haplotype H1+ (H1/H1 and H1/Hn genotypes) is significantly higher in alcoholics and alcoholic subgroups, including early onset drinkers and benders, than in their respective control groups. The Promoter -141C allele is in linkage disequilibrium (LD) with five other loci in the nonalcoholic group, but not in the alcoholic group. All of the other five loci are in LD in both the alcoholic and control groups. The DRD2 TaqI B allele is in complete LD with the allele located in intron 6. Five SNPs, Promoter -141C, TaqI B (or Intron 6), Exon 7, Exon 8, and TaqI A, are sufficient to define the DRD2 haplotypes in Mexican Americans. Our data indicate that the DRD2 haplotypes are associated with alcoholism in Mexican Americans. |
| 收录类别 | SCI |
| 资助信息 | This work is supported bygrantfromNationalInstitutesofHealthNational Institute on Alcohol Abuse and Alcoholism RO1 AA12081, the Na- tional Natural Science Foundation of China (30021004), National Key Technologies R&D Program of China and Science, and Technology Committee of Yunnan Province (2004BA901A07). |
| 原文出处 | 200536117.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4149]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_细胞与分子进化开放实验室 管理、支撑部门_计划财务处 |
| 作者单位 | 1.Department of Pharmacology, Toxicology & Therapeutics, Breidenthal Building, Mail Stop 1018, The University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160-7417, USA 2.Laboratory of Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, PR China 3.Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China |
| 推荐引用方式 GB/T 7714 | Luo HR,Hou ZF,Wu JL,et al. Evolution of the DRD2 gene haplotype and its association with alcoholism in Mexican Americans[J]. ALCOHOL,2005,36(2):117-125. |
| APA | Luo HR,Hou ZF,Wu JL,Zhang YP,&Wan YJY[*].(2005).Evolution of the DRD2 gene haplotype and its association with alcoholism in Mexican Americans.ALCOHOL,36(2),117-125. |
| MLA | Luo HR,et al."Evolution of the DRD2 gene haplotype and its association with alcoholism in Mexican Americans".ALCOHOL 36.2(2005):117-125. |
入库方式： OAI收割
来源：昆明动物研究所
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