Identification of genes differentially expressed in wild type and Purkinje cell degeneration mice
文献类型：期刊论文
| 作者 | Xiao R1,2; Park Y3; Dirisala VR1,3; Zhang YP2; Um SJ1; Lee HT1; Park C[*]1 |
| 刊名 | MOLECULES AND CELLS
 |
| 出版日期 | 2005 |
| 卷号 | 20期号:2页码:219-227 |
| 关键词 | Agtpbp1 cerebellum gene expression microarray pcd Purkinje cell degeneration |
| ISSN号 | 1016-8478 |
| 通讯作者 | chankyu@konkuk.ac.kr |
| 合作状况 | 其它 |
| 英文摘要 | Purkinje cell degeneration (pcd) mice are characterized by death of virtually all cerebellar Purkinje cells by postnatal day 30. In this study, we used DNA microarray analysis to investigate differences in gene expression between the brains of wild type and pcd mice on postnatal day 20, before the appearance of clear-cut phenotypic abnormalities. We identified 300 differentially expressed genes, most of which were involved in metabolic and physiological processes. Among the differentially expressed genes were several calcium binding proteins including calbindin -28k, paravalbumin, matrix gamma-carboxygluta mate protein and synaptotagamins 1 and 13, suggesting the involvement of abnormal Ca2+ signaling in the pcd phenotype. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the faculty research fund of Konkuk University in 2004. |
| 原文出处 | 200520219.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4155]  |
| 专题 | 昆明动物研究所_分子进化基因组学 |
| 作者单位 | 1.Department of Animal Biotechnology; Bio-Organ Research Center/Institute of Biomedical Science and Technology, Konkuk Univer- sity, Seoul 143-701, Korea 2.Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China; Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 3.Department of Animal Biotechnology, Cheju National University, Jeju 690-751, Korea |
| 推荐引用方式 GB/T 7714 | Xiao R,Park Y,Dirisala VR,et al. Identification of genes differentially expressed in wild type and Purkinje cell degeneration mice[J]. MOLECULES AND CELLS,2005,20(2):219-227. |
| APA | Xiao R.,Park Y.,Dirisala VR.,Zhang YP.,Um SJ.,...&Park C[*].(2005).Identification of genes differentially expressed in wild type and Purkinje cell degeneration mice.MOLECULES AND CELLS,20(2),219-227. |
| MLA | Xiao R,et al."Identification of genes differentially expressed in wild type and Purkinje cell degeneration mice".MOLECULES AND CELLS 20.2(2005):219-227. |
入库方式： OAI收割
来源：昆明动物研究所
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