Composition and evolution of the V2r vorneronasal receptor gene repertoire in mice and rats
文献类型：期刊论文
| 作者 | Yang H1,2; Shi P3; Zhang YP[*]1,4; Zhang JZ[*]3 |
| 刊名 | GENOMICS
 |
| 出版日期 | 2005 |
| 卷号 | 86期号:3页码:306-315 |
| 关键词 | Evolution Rodents Pheromone receptor Mouse Rat Vomeronasal Gene family |
| ISSN号 | 0888-7543 |
| 通讯作者 | zhangyp1@263.net.cn ; jianzhi@umich.edu |
| 合作状况 | 其它 |
| 英文摘要 | Pheromones are chemicals produced and detected by conspecifics to elicit social/sexual physiological and behavioral responses, and they are perceived primarily by the vomeronasal organ (VNO) in terrestrial vertebrates. Two large superfamilies of G protein-coupled receptors, V1rs and V2rs, have been identified as pheromone receptors in vomeronasal sensory neurons. Based on a computational analysis of the mouse and rat genome sequences, we report the first global draft of the V2r gene repertoire, composed of approximately 200 genes and pseudogenes. Rodent V2rs are subject to rapid gene births/deaths and accelerated amino acid substitutions, likely reflecting the species-specific nature of pheromones. Vertebrate V2rs appear to have originated twice prior to the emergence of the VNO in ancestral tetrapods, explaining seemingly inconsistent observations among different V2rs. The identification of the entire V2r repertoire opens the door to genomic-level studies of the structure, function, and evolution of this diverse group of sensory receptors. |
| 收录类别 | SCI |
| 资助信息 | This work was supported in part by a National Institutes of Health grant (GM67030) to J.Z. and grants from National Natural Science Foundation of China (30021004 and 30430110), Natural Science Foundation of Yunnan, and Chinese Academy of Sciences to Y.P.Z. |
| 原文出处 | 200586306.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4167]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_进化与功能基因组学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Graduate School of the Chinese Academy of Sciences, Beijing, China 3.Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, USA 4.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China |
| 推荐引用方式 GB/T 7714 | Yang H,Shi P,Zhang YP[*],et al. Composition and evolution of the V2r vorneronasal receptor gene repertoire in mice and rats[J]. GENOMICS,2005,86(3):306-315. |
| APA | Yang H,Shi P,Zhang YP[*],&Zhang JZ[*].(2005).Composition and evolution of the V2r vorneronasal receptor gene repertoire in mice and rats.GENOMICS,86(3),306-315. |
| MLA | Yang H,et al."Composition and evolution of the V2r vorneronasal receptor gene repertoire in mice and rats".GENOMICS 86.3(2005):306-315. |
入库方式： OAI收割
来源：昆明动物研究所
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