The unusual adaptive expansion of pancreatic ribonuclease gene in carnivora
文献类型：期刊论文
| 作者 | Yu L1,2; Zhang YP[*]1,2 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2006 |
| 卷号 | 23期号:12页码:2326-2335 |
| 关键词 | RNASE1 Carnivora Mustelidae enzyme activity positive selection |
| ISSN号 | 0737-4038 |
| 通讯作者 | zhangyp1@263.net.cn |
| 合作状况 | 其它 |
| 英文摘要 | Pancreatic ribonuclease (RNASE1) is a digestive enzyme that has been recognized to be one of the most attractive model systems for molecular evolutionary studies. The contribution of RNASE1 gene duplication to the functional adaptation of digestive physiology in foregut-fermenting herbivores, mostly in ruminants, has been well documented. However, no one has ever done a comprehensive study on the carnivores, which are sister to the artiodactyls. Here, we sequenced this gene from 15 species of the superfamily Caniformia in order Carnivora, which all have a relatively simple digestive system and lack the microbial digestion in rumen or cecum typical of most herbivores. In contrast to our initial expectation that only a single RNASE1 gene is present in these carnivores, we observed a "birth (gene duplication)-and-death (gene deactivation)" process for the evolution of RNASE1 genes in all 3 species of Mustelidae family examined here, adding the growing diversity of RNASE1 gene family evolution. In addition, bursts of positive selection have been shown to contribute the enigmatic diversification of these RNASE1 genes in Mustelidae. The finding of the adaptive expansion of RNASE1 in animals without foregut fermentation provides another opportunity for further studies of the structure, function, and evolution of this gene, raising the possibility that new tissue specificity or other functions of RNASE1 genes might have developed in these species. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by a start-up fundfrom theUniversity ofYunnanand bygrants from National Natural Science Foundation of China (30430110) to Y.P.Z. |
| 原文出处 | 2006232326.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4191]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming, China 2.Laboratory of Molecular Biology of Domestic Animals, and Cellular and Molecular Evolution, Kunming Institute of Zoology, Kunming, China |
| 推荐引用方式 GB/T 7714 | Yu L,Zhang YP[*]. The unusual adaptive expansion of pancreatic ribonuclease gene in carnivora[J]. MOLECULAR BIOLOGY AND EVOLUTION,2006,23(12):2326-2335. |
| APA | Yu L,&Zhang YP[*].(2006).The unusual adaptive expansion of pancreatic ribonuclease gene in carnivora.MOLECULAR BIOLOGY AND EVOLUTION,23(12),2326-2335. |
| MLA | Yu L,et al."The unusual adaptive expansion of pancreatic ribonuclease gene in carnivora".MOLECULAR BIOLOGY AND EVOLUTION 23.12(2006):2326-2335. |
入库方式： OAI收割
来源：昆明动物研究所
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