Somatic mutations of mitochondrial genome in early stage breast cancer
文献类型：期刊论文
| 作者 | Wang CY1,3; Wang HW2; Yao YG1; Kong QP[*]1,2; Zhang YP[*]1,2 |
| 刊名 | INTERNATIONAL JOURNAL OF CANCER
 |
| 出版日期 | 2007 |
| 卷号 | 121期号:6页码:1253-1256 |
| 关键词 | mtDNA cancer somatic mutation haplotype phylogeny |
| ISSN号 | 0020-7136 |
| 通讯作者 | kongqp@yahoo.com.cn |
| 合作状况 | 其它 |
| 英文摘要 | The complete mitochondrial genomes of the primary cancerous, matched paracancerous normal and distant normal tissues from 10 early-stage breast cancer patients were analyzed in this study, with special attempt (i) to investigate whether the reported high frequency of mitochondrial DNA (mtDNA) somatic mutations in breast cancer could be repeated under a stringent data quality control, and (ii) to characterize the spectrum of mtDNA somatic mutations in Chinese breast cancer patients and evaluate their potential significance in early cancer diagnosis. Two heteroplasmic somatic transitions (T2275C and A8601G) were identified in our samples. The transition A8601G was present in the primary cancerous and paracancerous normal tissues from patient no. 3. Transition T2275C was found in the primary cancerous tissue but not in other normal tissues from patient no. 6; this transition has been reported in the colonic crypts and is located at a highly conserved site in the 16S rRNA gene. Subsequent cloning sequencing confirmed the absence of both mutations in the distant normal tissues from the 2 patients. The overall rate of somatic mutations in our patients was much lower than those of previous studies of breast cancer. Our results gave support to the recent claim that the high frequency of mtDNA somatic mutations in cancer studies is overestimated. Based on the mtDNA mutation pattern in early stage breast cancer observed in this study, we cautioned the enthusiasm and efforts to look for somatic mutations that were of diagnostic value in cancer early detection. |
| 收录类别 | SCI |
| 资助信息 | Natural Science Foundation of China (NSFC); Grant number: 30621092; Grant sponsor: Science and Technology Committee of Yunnan Province; Grant number: 2005PG11. |
| 原文出处 | 20071211253.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4237]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_分子人类学 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China 3.Graduate University of the Chinese Academy of Sciences, Beijing 100049, China |
| 推荐引用方式 GB/T 7714 | Wang CY,Wang HW,Yao YG,et al. Somatic mutations of mitochondrial genome in early stage breast cancer[J]. INTERNATIONAL JOURNAL OF CANCER,2007,121(6):1253-1256. |
| APA | Wang CY,Wang HW,Yao YG,Kong QP[*],&Zhang YP[*].(2007).Somatic mutations of mitochondrial genome in early stage breast cancer.INTERNATIONAL JOURNAL OF CANCER,121(6),1253-1256. |
| MLA | Wang CY,et al."Somatic mutations of mitochondrial genome in early stage breast cancer".INTERNATIONAL JOURNAL OF CANCER 121.6(2007):1253-1256. |
入库方式： OAI收割
来源：昆明动物研究所
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