Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children
文献类型：期刊论文
| 作者 | Chan IHS1; Tang NLS1,3; Leung TF2; Ma SL1; Zhang YP4; Wong GWK2; Wong CK1; Lam CWK[*]1,5 |
| 刊名 | ALLERGY
 |
| 出版日期 | 2007 |
| 卷号 | 62期号:7页码:802-809 |
| 关键词 | prostaglandin-endoperoxide synthase 2 gene aeroallergen asthma genetic polymorphism immunogobulin E |
| ISSN号 | 0105-4538 |
| 合作状况 | 其它 |
| 英文摘要 | Background: Cyclooxygenase-2 (COX-2) plays essential roles in inflammation. Previous studies have suggested associations between prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and prostaglandins production in asthma. Objective: We have investigated the effects of Chinese tagging single nucleotide polymorphisms (SNPs) of PTGS2 on asthma traits in 299 Chinese asthmatic children and 175 controls. Methods: Plasma total and allergen-specific IgE were measured by enzyme immunoassay. PTGS2.8473T -> C in the 3'-untranslated region of exon 10 and three tag SNPs covering most of the variations in PTGS2 haplotypes in Chinese were genotyped by restriction fragment length polymorphism. Results: Among the four SNPs, only PTGS2.8473 showed significant association with asthma (P = 0.034) and atopy (P = 0.005 when compared with nonatopic controls; P = 0.023 with all controls). Carriers of the C allele had a 1.5-fold (95% confidence interval: 1.01-2.30) risk of developing asthma than those homozygous for the T allele. Multivariate regression revealed significant correlations between PTGS2.8473 and forced expiratory volume in 1 s (FEV1; P = 0.002) and peak expiratory flow rate (PEFR; P = 0.001) with, age and gender adjusted. Patients with the C allele of PTGS2.8473 had significantly lower FEV1 (median: 90.0% vs 98.0%; P = 0.0047) and PEFR (70.0% vs 73.5%; P = 0.0065) than those homozygous for the T allele. No significant association between plasma total and allergen-specific IgE and these SNPs or with their haplotypes was found. Conclusions: PTGS2.8473 polymorphism is associated with asthma, atopy and lung function but not plasma IgE in Chinese children. This may help to explore the pharmacogenetics of COX-2 inhibitors. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by a Direct Grant for Research of the Chinese University of Hong Kong and a donation from Kelly Cheng of GreaterChina Technology Group Ltd for research in al- lergy and clinical immunology. |
| 原文出处 | 200762802.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4241]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Department of Chemical Pathology,The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong 2.Department of Paediatrics,The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong 3.Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong 4.Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 5.Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau |
| 推荐引用方式 GB/T 7714 | Chan IHS,Tang NLS,Leung TF,et al. Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children[J]. ALLERGY,2007,62(7):802-809. |
| APA | Chan IHS.,Tang NLS.,Leung TF.,Ma SL.,Zhang YP.,...&Lam CWK[*].(2007).Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children.ALLERGY,62(7),802-809. |
| MLA | Chan IHS,et al."Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children".ALLERGY 62.7(2007):802-809. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。