Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population
文献类型：期刊论文
| 作者 | Fu WP1,2; Sun C3; Dai LM[*]2; Yang LF2; Zhang YP[*]1,3 |
| 刊名 | ONCOLOGY REPORTS
 |
| 出版日期 | 2007 |
| 卷号 | 17期号:2页码:483-488 |
| 关键词 | chronic obstructive pulmonary disease microsomal epoxide hydrolase heme oxygenase polymorphism |
| ISSN号 | 1021-335X |
| 通讯作者 | dailuming@hotmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Recent studies have proposed that susceptibility to chronic obstructive pulmonary disease (COPD) might be related with the polymorphisms of some genes encoding antioxidant enzymes, such as heme oxygenase-1 (HOX-1) and microsomal epoxide hydrolase (mEPH). We examined these polymorphisms in 256 patients with COPD and 266 healthy smokers from Han population in Southwest China. The frequencies of each allele were compared both individually and in combination between patients and controls. Polymorphisms of HOX-1 gene could be grouped into three classes: S (>= 25 repeat), M (26-31 repeat), and L (>= 32 repeat). The allele frequencies of class L and the genotypic frequencies of the group with L were significantly higher in COPD than in controls. Our findings also showed that the proportion of slow mEPH activity was significantly higher in COPD than in controls. Conversely, the proportion of fast mEPH activity was significantly lower in COPD. In combined analysis, the frequency of the individuals having at least one L allele in the HOX-1 gene promoter and slow or very slow activity genotype for mEPH was higher in COPD than in control. Genetic polymorphisms in HOX-1 and mEPH genes are associated with the development of COPD in Southwest China. |
| 收录类别 | SCI |
| 资助信息 | This study was funded by the Science and Technology Committee of Yunnan Province (2005NG07), Chinese Academy of Sciences, and National Natural Science Foundation of China (NSFC). |
| 原文出处 | 200717438.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4259]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091 2.Department of Respiratory Critical Care Medicine, The First Affiliated Hospital of Kunming Medical College 3.Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P.R. China |
| 推荐引用方式 GB/T 7714 | Fu WP,Sun C,Dai LM[*],et al. Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population[J]. ONCOLOGY REPORTS,2007,17(2):483-488. |
| APA | Fu WP,Sun C,Dai LM[*],Yang LF,&Zhang YP[*].(2007).Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population.ONCOLOGY REPORTS,17(2),483-488. |
| MLA | Fu WP,et al."Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population".ONCOLOGY REPORTS 17.2(2007):483-488. |
入库方式： OAI收割
来源：昆明动物研究所
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