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Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection

文献类型：期刊论文

作者Li H1,2,3,4; Tang NLS4,5,6; Chan PKS7,8; Wang CY1,2,3,4; Hui DSC8,9; Luk C6; Kwok R6; Huang W4,5,6; Sung JJY7,8; Kong QP1,2,4
刊名JOURNAL OF MEDICAL GENETICS
出版日期2008
卷号45期号:11页码:752-758
ISSN号0022-2593
通讯作者zhangyp1@263.net.cn
合作状况其它
英文摘要Background: Polymorphisms of CLEC4M have been associated with predisposition for infection by the severe acute respiratory syndrome coronavirus (SARS-CoV). DC-SIGNR, a C-type lectin encoded by CLEC4M, is a receptor for the virus. A variable number tandem repeat (VNTR) polymorphism in its neck region was recently associated with susceptibility to SARS infection. However, this association was controversial and was not supported by subsequent studies. Two explanations may account for this discrepancy: (1) there may be an unknown predisposition polymorphism located in the proximity which is linked to the VNTR; or (2) it was a spurious association due to unrecognised population structure in the VNTR. Methods: We performed a comprehensively genetic association study on this C-type lectin gene cluster (FCER2, CLEC4G, CD209, and CLEC4M) at 19p13.3 by a tagging single nucleotide polymorphisms (SNPs) approach. Results: 23 tagSNPs were genotyped in 181 SARS patients and 172 population controls. No significant association with disease predisposition was detected. Genetic variations in this cluster also did not predict disease prognosis. However, we detected a population stratification of the VNTR alleles in a sample of 1145 Han Chinese collected from different parts of China. Conclusion: The results indicated that the genetic predisposition allele was not found in this lectin gene cluster and population stratification might cause the previous positive association.
收录类别其他
资助信息This work was supported by grants the National Natural Science Foundation of China (30621092), Bureau of Science and Technology of Yunnan Province and a Direct grant from the Faculty of Medicine, The Chinese University of Hong Kong (2007.1.019).
原文出处200845752.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/4275]  
专题昆明动物研究所_分子进化基因组学
昆明动物研究所_遗传资源与进化国家重点实验室
昆明动物研究所_分子人类学
作者单位1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
2.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming, China
3.Graduate University of the Chinese Academy of Sciences, Beijing, China
4.KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China
5.Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
6.Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
7.Departments of Microbiology, The Chinese University of Hong Kong, Hong Kong, China
8.Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China
9.Departments of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
推荐引用方式
GB/T 7714		 Li H,Tang NLS,Chan PKS,et al. Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection[J]. JOURNAL OF MEDICAL GENETICS,2008,45(11):752-758.
APA Li H.,Tang NLS.,Chan PKS.,Wang CY.,Hui DSC.,...&Zhang YP[*].(2008).Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection.JOURNAL OF MEDICAL GENETICS,45(11),752-758.
MLA Li H,et al."Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection".JOURNAL OF MEDICAL GENETICS 45.11(2008):752-758.

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来源：昆明动物研究所

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