Association of pro staglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese
文献类型：期刊论文
| 作者 | Ma SL1,2; Tang NLS1; Zhang YP3; Ji LD3,4; Tam CWC2; Lui VWC2; Chiu HFK2,5; Lam LCW[*]2 |
| 刊名 | NEUROBIOLOGY OF AGING
 |
| 出版日期 | 2008 |
| 卷号 | 29期号:6页码:856-860 |
| 关键词 | Alzheimer's disease PTGS2 polymorphisms Chinese |
| ISSN号 | 0197-4580 |
| 通讯作者 | cwlam@cuhk.edu.hk |
| 合作状况 | 其它 |
| 英文摘要 | Cyclooxygenase-2 (COX-2, encoded by the gene prostaglandin-endoperoxide synthase 2, PTGS2) is a key enzyme in the conversion of arachidonic acid to prostaglandins. The prostaglandins produced by COX-2 are involved in inflammation and pain response in different tissues in the body. Enhanced COX-2 expression had been found in regions of brains from patients with Alzheimer's disease (AD). Here, we proceeded to test the hypothesis that polymorphisms of the PTGS2 gene predispose to AD. IVS5-275 T>G and Ex10+837 T>C in addition to three tagging SNPs from HapMap database, which provided a comprehensive coverage of genetic variations in the PTGS2 gene in Chinese were -enotyped among 257 AD patients and 244 age-matched healthy Chinese subjects. Genetic associations were analyzed by chi(2)-test and haplotypes analysis. Although the previously reported protective polymorphism (rs20417, -765 G/C) for AD in PTGS2 gene was not polymorphic in the Chinese population, SNPs in both the promoter (-2319 G>T) and 3' region (ExIO+837 T>C) of PTGS2 were associated with the risk of AD (p = 0.01 and 0.03, respectively). Carriers of ExIO+837 T allele had a 1.5-fold increase in the risk of AD. This study suggested that PTGS2 gene was a predisposition gene and arachidonic acid metabolism might be involved in the pathogenesis of AD. It provided further evidence to support a role of inflammation in the development and progression of AD. |
| 收录类别 | SCI |
| 原文出处 | 200829856.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4293]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China 2.Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China 3.Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 4.Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, China 5.Jockey Club Centre for Positive Ageing, Hong Kong, China |
| 推荐引用方式 GB/T 7714 | Ma SL,Tang NLS,Zhang YP,et al. Association of pro staglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese[J]. NEUROBIOLOGY OF AGING,2008,29(6):856-860. |
| APA | Ma SL.,Tang NLS.,Zhang YP.,Ji LD.,Tam CWC.,...&Lam LCW[*].(2008).Association of pro staglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese.NEUROBIOLOGY OF AGING,29(6),856-860. |
| MLA | Ma SL,et al."Association of pro staglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese".NEUROBIOLOGY OF AGING 29.6(2008):856-860. |
入库方式： OAI收割
来源：昆明动物研究所
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