A Profound Role for the Expansion of Trypsin-Like Serine Protease Family in the Evolution of Hematophagy in Mosquito
文献类型：期刊论文
| 作者 | Wu DD1,2; Wang GD1,2; Irwin DM3,4; Zhang YP[*]1,2,5 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2009 |
| 卷号 | 26期号:10页码:2333-2341 |
| 关键词 | Tryp_SPc trypsin-like serine protease gene family mosquito hematophagy positive selection |
| ISSN号 | 0737-4038 |
| 通讯作者 | zhangyp1@263.net.cn |
| 合作状况 | 其它 |
| 英文摘要 | The trypsin-like serine protease (Tryp_SPc) family is ubiquitous in animals and plays diverse roles, especially in the digestive system, in different phyla. In the mosquito, some Tryp_SPc proteases make important contributions to the digestion of the blood meal. Here, we have defined the complete Tryp_SPc gene repertoire in the genome of the malaria mosquito, a repertoire that has expanded remarkably compared with that of Drosophila. Phylogenetic analysis also indicates that the large-scale lineage-specific expansion occurred leading to mosquitoes. Expression of Tryp_SPc genes elevates after a blood meal, and the expression level of genes that belong to subfamilies that specifically expanded on the mosquito lineage increased significantly more than genes that belong to subfamilies that did not expand in number, suggesting a profound role for the Tryp_SPc genes, especially the expanded subfamilies, in the hematophagous trait of the mosquito. The mosquito Tryp_SPc genes are mostly distributed in a tandem manner on chromosomes, suggesting a role for tandem duplication in the expansion of the subfamilies. Furthermore, evidence for positive selection was found for some genes. Structural modeling indicates that the positively selected sites locate to the Surface that is conjugated by protein inhibitors. Our results suggest that the expansion and diversification of the Tryp_SPc domain family in mosquito was driven by positive selection and helps to explain the adaptive hematophagy of the mosquito. |
| 收录类别 | SCI |
| 资助信息 | This work was sup- ported by grants from the National Basic Research Program of China (973 Program, 2007CB411600), the National Natural Science Foundation of China (30621092, 30430110), and Bureau of Science and Technology of Yunnan Province. |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4309]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_进化与发育转录组学 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Graduate School of the Chinese Academy of Sciences, Beijing, China 3.Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada 4.Banting and Best Diabetes Centre, University of Toronto, Ontario, Canada 5.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming, China |
| 推荐引用方式 GB/T 7714 | Wu DD,Wang GD,Irwin DM,et al. A Profound Role for the Expansion of Trypsin-Like Serine Protease Family in the Evolution of Hematophagy in Mosquito[J]. MOLECULAR BIOLOGY AND EVOLUTION,2009,26(10):2333-2341. |
| APA | Wu DD,Wang GD,Irwin DM,&Zhang YP[*].(2009).A Profound Role for the Expansion of Trypsin-Like Serine Protease Family in the Evolution of Hematophagy in Mosquito.MOLECULAR BIOLOGY AND EVOLUTION,26(10),2333-2341. |
| MLA | Wu DD,et al."A Profound Role for the Expansion of Trypsin-Like Serine Protease Family in the Evolution of Hematophagy in Mosquito".MOLECULAR BIOLOGY AND EVOLUTION 26.10(2009):2333-2341. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。