Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population
文献类型：期刊论文
| 作者 | Yang JK1; Gong YY2; Xie L1,3; Lian SG4; Yang J4; Xu LY5; Gao SJ5; Zhang YP[*]1,2 |
| 刊名 | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
 |
| 出版日期 | 2009 |
| 卷号 | 10期号:2页码:115-118 |
| 关键词 | angiotensin-converting enzyme Han Chinese population longevity polymorphism |
| ISSN号 | 1470-3203 |
| 通讯作者 | zhangyp1@263.net.cn |
| 合作状况 | 其它 |
| 英文摘要 | Introduction. The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene has been reported to associate with human longevity. However, little information is available in a Han Chinese longevity Population. Therefore, we investigated the association of the ACE gene insertion/deletion polymorphism with longevity in a Han Chinese population. Materials and methods. We compared the distribution of ACE insertion/deletion genotype and allele frequencies in two groups: a longevity group (399 subjects) aged over 90 years and a control group (302 subjects) aged less than 60 years. Results. No difference in genotype and allele frequencies of the ACE gene insertion/deletion polymorphism was observed between the longevity group and the control group. When adjusting for gender, the difference between the longevity group and the control group was also not significant regarding the frequencies of the genotypes (male, p=0.994 and female, p=0.797) as well as allele frequencies (male, p=0.969 and female, p=0.884). Conclusions. No association of the ACE gene insertion/deletion polymorphism with longevity was observed in our Han Chinese population. |
| 学科主题 | Peripheral Vascular Disease |
| 收录类别 | SCI |
| 资助信息 | This work was Supported by grants from the National Basic Research Programme of China (No. 2007CB507405) and NSFC. |
| 原文出处 | 2009102115.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4319]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Laboratory for Conservation and Utilisation of Bio-resource, Yunnan University, Kunming, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Graduate University of the Chinese Academy of Sciences, Beijing, China 4.People’s Hospital of Dujiang Weirs City, Dujiang Weirs City, China 5.Dujiangyan Longevity Research Centre, Dujiangyan, China |
| 推荐引用方式 GB/T 7714 | Yang JK,Gong YY,Xie L,et al. Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population[J]. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM,2009,10(2):115-118. |
| APA | Yang JK.,Gong YY.,Xie L.,Lian SG.,Yang J.,...&Zhang YP[*].(2009).Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population.JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM,10(2),115-118. |
| MLA | Yang JK,et al."Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population".JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 10.2(2009):115-118. |
入库方式： OAI收割
来源：昆明动物研究所
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