Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic children
文献类型：期刊论文
| 作者 | Chan IHS1; Tang NLS1,2,3; Leung TF3,4; Huang W1; Lam YYO1; Wong GWK4; Chan JCN5; Chan MHM1; Wong CK1; Zhang YP3,6 |
| 刊名 | PEDIATRIC ALLERGY AND IMMUNOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 20期号:2页码:142-150 |
| 关键词 | aeroallergen asthma early growth response-1 genetic polymorphism immunoglobulin E |
| ISSN号 | 0905-6157 |
| 通讯作者 | waikeilam@cuhk.edu.hk |
| 合作状况 | 其它 |
| 英文摘要 | Early growth response-1 (Egr-1) is expressed in human airways and found to modulate tumor necrosis factor, immunoglobulin E (IgE), airway responsiveness, and interleukin-13-induced inflammation in mice. We investigated the effects of Chinese-tagging single nucleotide polymorphisms (SNPs) of Egr-1 on asthma traits in 298 Chinese asthmatic children and 175 controls, and a replication community cohort of 191 controls. Tag SNP (-4071 A -> G) and three additional SNPs (-1427 C -> T, -151 C -> T and IVS1 -42 C -> T) were genotyped by restriction fragment length polymorphism (RFLP). Significant associations were found between plasma total IgE concentration and -4071 A -> G (p = 0.008) and IVS1 -42 C -> T (p = 0.027) in asthmatic patients. After Bonferroni correction, only -4071 A -> G showed significant association. Multivariate regression analysis confirmed this significant association with a standardized coefficient beta of 0.156 (95% CI: 0.046-0.317; p = 0.009) in asthmatics among the three SNPs with age and gender-adjusted. In -4071 A -> G, IgE(log) was significantly higher in patients with the GG genotype than the AA genotype (p = 0.009). In addition, -4071 A -> G was significantly associated with atopy (p = 0.016) and high total IgE concentration (p = 0.030) among asthmatics. Patients with the G allele had a 3.5-fold risk of having atopy and a 2.0-fold risk of having high total IgE concentration than those homozygous for the A allele. This is the first report to show significant association of Egr-1 polymorphisms with plasma total IgE and atopy in asthmatics. It may help to explore the pharmacogenetics of Egr-1 inhibitors. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by a Direct Grant for Research of the Chinese University of Hong Kong. We thank patients and controls for participating in this project, and Chung-yi Li and Edmund Yung for performing spirometry in recruited patients. |
| 原文出处 | 2009202142.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4335]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Department of Chemical Patholog,The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong 2.Li Ka Shing Institute of Health Sciences,The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan 4.Paediatrics and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong 5.Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong 6.Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 7.Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology Foundation, Macau |
| 推荐引用方式 GB/T 7714 | Chan IHS,Tang NLS,Leung TF,et al. Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic children[J]. PEDIATRIC ALLERGY AND IMMUNOLOGY,2009,20(2):142-150. |
| APA | Chan IHS.,Tang NLS.,Leung TF.,Huang W.,Lam YYO.,...&Lam CWK[*].(2009).Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic children.PEDIATRIC ALLERGY AND IMMUNOLOGY,20(2),142-150. |
| MLA | Chan IHS,et al."Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic children".PEDIATRIC ALLERGY AND IMMUNOLOGY 20.2(2009):142-150. |
入库方式： OAI收割
来源：昆明动物研究所
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