Characterization of TRPC2, an Essential Genetic Component of VNS Chemoreception, Provides Insights into the Evolution of Pheromonal Olfaction in Secondary-Adapted Marine Mammals
文献类型：期刊论文
| 作者 | Yu L[*]1; Jin W1,2; Wang JX1; Zhang X1; Chen MM3; Zhu ZH1; Lee H4; Lee MY4; Zhang YP[*]1,2 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2010 |
| 卷号 | 27期号:7页码:1476-1477 |
| ISSN号 | 0737-4038 |
| 关键词 | vomeronasal system TRPC2 marine mammals pheromones |
| 通讯作者 | yuli1220@yahoo.com.cn ; zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Pheromones are chemical cues released and sensed by individuals of the same species, which are of major importance in regulating reproductive and social behaviors of mammals. Generally, they are detected by the vomeronasal system (VNS). Here, we first investigated and compared an essential genetic component of vomeronasal chemoreception, that is, TRPC2 gene, of four marine mammals varying the degree of aquatic specialization and related terrestrial species in order to provide insights into the evolution of pheromonal olfaction in the mammalian transition from land to water. Our results based on sequence characterizations and evolutionary analyses, for the first time, show the evidence for the ancestral impairment of vomeronasal pheromone signal transduction pathway in fully aquatic cetaceans, supporting a reduced or absent dependence on olfaction as a result of the complete adaptation to the marine habitat, whereas the amphibious California sea lion was found to have a putatively functional TRPC2 gene, which is still under strong selective pressures, reflecting the reliance of terrestrial environment on chemical recognition among the semiadapted marine mammals. Interestingly, our study found that, unlike that of the California sea lion, TRPC2 genes of the harbor seal and the river otter, both of which are also semiaquatic, are pseudogenes. Our data suggest that other unknown selective pressures or sensory modalities might have promoted the independent absence of a functional VNS in these two species. In this respect, the evolution of pheromonal olfaction in marine mammals appears to be more complex and confusing than has been previously thought. Our study makes a useful contribution to the current understanding of the evolution of pheromone perception of mammals in response to selective pressures from an aquatic environment. |
| 资助信息 | This work was supported by grants from the State Key Basic Research and Development Plan (2007CB411600); National Natural Science Foundation of China (U0836603 and 30621092); National Undergraduate Students Research Training Fund from Ministry of Education of the People’s Republic of China; National Fund for Fostering Talents of Basic Science (Grant No. J0730652); Research Training Fund from Exper- iment Teaching Center of Life Sciences; and Project of Higher Education Reform and Practice of Science and Engineering from Ministry of Education of the People’s Republic of China (Grant No. 239). |
| 收录类别 | SCI |
| 原文出处 | 20102771467.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4345]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Laboratory for Conservation and Utilization of Bio-resource and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, People’s Republic of China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.The School of Life Science, Yunnan University, Kunming, China 4.Conservation Genome Resource Bank for Korean Wildlife, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea |
| 推荐引用方式 GB/T 7714 | Yu L[*],Jin W,Wang JX,et al. Characterization of TRPC2, an Essential Genetic Component of VNS Chemoreception, Provides Insights into the Evolution of Pheromonal Olfaction in Secondary-Adapted Marine Mammals[J]. MOLECULAR BIOLOGY AND EVOLUTION,2010,27(7):1476-1477. |
| APA | Yu L[*].,Jin W.,Wang JX.,Zhang X.,Chen MM.,...&Zhang YP[*].(2010).Characterization of TRPC2, an Essential Genetic Component of VNS Chemoreception, Provides Insights into the Evolution of Pheromonal Olfaction in Secondary-Adapted Marine Mammals.MOLECULAR BIOLOGY AND EVOLUTION,27(7),1476-1477. |
| MLA | Yu L[*],et al."Characterization of TRPC2, an Essential Genetic Component of VNS Chemoreception, Provides Insights into the Evolution of Pheromonal Olfaction in Secondary-Adapted Marine Mammals".MOLECULAR BIOLOGY AND EVOLUTION 27.7(2010):1476-1477. |
入库方式： OAI收割
来源：昆明动物研究所
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