Evidence for Positive Selection on the Osteogenin (BMP3) Gene in Human Populations
文献类型：期刊论文
| 作者 | Wu DD1,3; Jin W2; Hao XD1,3; Tang NLS4,5,6; Zhang YP[*]1,2,4 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2010 |
| 卷号 | 5期号:6页码:e10959 |
| ISSN号 | 1932-6203 |
| 通讯作者 | zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Background: Human skeletal system has evolved rapidly since the dispersal of modern humans from Africa, potentially driven by selection and adaptation. Osteogenin (BMP3) plays an important role in skeletal development and bone osteogenesis as an antagonist of the osteogenic bone morphogenetic proteins, and negatively regulates bone mineral density. Methodology/Principal Findings: Here, we resequenced the BMP3 gene from individuals in four geographically separated modern human populations. Features supportive of positive selection in the BMP3 gene were found including the presence of an excess of nonsynonymous mutations in modern humans, and a significantly lower genetic diversity that deviates from neutrality. The prevalent haplotypes of the first exon region in Europeans demonstrated features of long-range haplotype homogeneity. In contrast with findings in European, the derived allele SNP Arg192Gln shows higher extended haplotype homozygosity in East Asian. The worldwide allele frequency distribution of SNP shows not only a high-derived allele frequency in Asians, but also in Americans, which is suggestive of functional adaptation. Conclusions/Significance: In conclusion, we provide evidence for recent positive selection operating upon a crucial gene in skeletal development, which may provide new insight into the evolution of the skeletal system and bone development. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Basic Research Program of China (973 Program, 2007CB411600), the National Natural Science Foundation of China (30621092, 30430110), and Bureau of Science and Technology of Yunnan Province. |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4353]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_进化与发育转录组学 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming, China 3.Graduate School of the Chinese Academy of Sciences, Beijing, China 4.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China 5.Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People’s Republic of China 6.Laboratory for Genetics of Disease Susceptibility, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Wu DD,Jin W,Hao XD,et al. Evidence for Positive Selection on the Osteogenin (BMP3) Gene in Human Populations[J]. PLOS ONE,2010,5(6):e10959. |
| APA | Wu DD,Jin W,Hao XD,Tang NLS,&Zhang YP[*].(2010).Evidence for Positive Selection on the Osteogenin (BMP3) Gene in Human Populations.PLOS ONE,5(6),e10959. |
| MLA | Wu DD,et al."Evidence for Positive Selection on the Osteogenin (BMP3) Gene in Human Populations".PLOS ONE 5.6(2010):e10959. |
入库方式： OAI收割
来源：昆明动物研究所
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