中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 昆明动物研究所
  3. 昆明动物研究所
  4. 遗传资源与进化国家重点实验室
  5. 分子进化基因组学
Adaptive evolution of energy metabolism genes and the origin of flight in bats

文献类型：期刊论文

作者Shen YY1,2,3; Liang L1,3; Zhu ZH2; Zhou WP1,4; Irwin DM5,6; Zhang YP[*]1,2
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
出版日期2010
卷号107期号:19页码:8666-8671
关键词Chiroptera genetic foundation mitochondria OXPHOS
ISSN号0027-8424
通讯作者zhangyp@mail.kiz.ac.cn
合作状况其它
英文摘要Bat flight poses intriguing questions about how flight independently developed in mammals. Flight is among the most energy-consuming activities. Thus, we deduced that changes in energy metabolism must be a primary factor in the origin of flight in bats. The respiratory chain of the mitochondrial produces 95% of the adenosine triphosphate (ATP) needed for locomotion. Because the respiratory chain has a dual genetic foundation, with genes encoded by both the mitochondrial and nuclear genomes, we examined both genomes to gain insights into the evolution of flight within mammals. Evidence for positive selection was detected in 23.08% of the mitochondrial-encoded and 4.90% of nuclear-encoded oxidative phosphorylation (OXPHOS) genes, but in only 2.25% of the nuclear-encoded nonrespiratory genes that function in mitochondria or 1.005% of other nuclear genes in bats. To address the caveat that the two available bat genomes are of only draft quality, we resequenced 77 OXPHOS genes from four species of bats. The analysis of the resequenced gene data are in agreement with our conclusion that a significantly higher proportion of genes involved in energy metabolism, compared with background genes, show evidence of adaptive evolution specific on the common ancestral bat lineage. Both mitochondrial and nuclear-encoded OXPHOS genes display evidence of adaptive evolution along the common ancestral branch of bats, supporting our hypothesis that genes involved in energy metabolism were targets of natural selection and allowed adaptation to the huge change in energy demand that were required during the origin of flight.
收录类别SCI
资助信息Supported by grants from United Funding of Yunnan Provincial Science and Technology Department and Kunming Medical College (2008C0005R to XFX), the National Natural Science Foundation of China (30530250 to LX and 30500150 to JC), the Science and Technology Foundation of Yunnan Province (2006PT08 to LX), and the 973 Program from the Ministry of Science and Technology of China (2006CB500808 and 2009CB941300 to LX; 2007CB512303 and 2009CB522006 to JC).
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/4359]  
专题昆明动物研究所_分子进化基因组学
昆明动物研究所_遗传资源与进化国家重点实验室
作者单位1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
2.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, China
3.Graduate School of the Chinese Academy of Sciences, Beijing 100000, China
4.Department of Molecular and Cell Biology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China
5.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 1A8
6.Banting and Best Diabetes Centre, University of Toronto, Toronto, ON, Canada M5S 1A8
推荐引用方式
GB/T 7714		 Shen YY,Liang L,Zhu ZH,et al. Adaptive evolution of energy metabolism genes and the origin of flight in bats[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(19):8666-8671.
APA Shen YY,Liang L,Zhu ZH,Zhou WP,Irwin DM,&Zhang YP[*].(2010).Adaptive evolution of energy metabolism genes and the origin of flight in bats.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(19),8666-8671.
MLA Shen YY,et al."Adaptive evolution of energy metabolism genes and the origin of flight in bats".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.19(2010):8666-8671.

入库方式： OAI收割

来源：昆明动物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。