The role of MC1R gene in buffalo coat color
文献类型：期刊论文
| 作者 | Miao YW1,2; Wu GS3; Wang L2; Li DL4; Tang SK5; Liang JP2; Mao HM2; Luo HR3; Zhang YP[*]1,6 |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2010 |
| 卷号 | 53期号:2页码:267-272 |
| 关键词 | Buffalo coat color MC1R |
| ISSN号 | 1674-7305 |
| 通讯作者 | zhangyp1@263.net.cn |
| 合作状况 | 其它 |
| 英文摘要 | Melanocortin-1 receptor (MC1R) plays a major role in pigmentation in many species. To investigate if the MC1R gene is associated with coat color in water buffalo, the coding region of MC1R gene of 216 buffalo samples was sequenced, which included 49 black river buffalo (Murrah and Nili-Ravi), 136 swamp buffalo (Dehong, Diandongnan, Dechang, Guizhou, and Xilin) with white and gray body, and 31 hybrid offspring of river buffalo Nili-Ravi (or Murrah) and swamp buffalo. Among the three variation sites found, SNP684 was synonymous, while SNP310 and SNP384 were nonsynonymous, leading to p.S104G and p.I128M changes, respectively. Only Individuals carrying homozygote E-BR/E-BR were black. The genotype and phenotype analysis of the hybrid offspring of black river buffalo and gray swamp buffalo further revealed that the river buffalo type allele E-BR or the allele carrying the amino acid p.104S was important for the full function of MC1R. The in silico functional analysis showed that the amino acid substitutions p.G104S and p.M128I had significant impact on the function of MC1R. Above results indicate that the allele E-BR or the allele carrying the amino acid p.104S was associated with the black coat color in buffalo. |
| 学科主题 | Biology |
| 收录类别 | 其他 |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (Grant Nos. 30660024 and 30621092), the National Major Projects for Transgenic organisms (Grant No. 2008ZX08009), Natural Science Foundation of Yunnan Province, China (Grant Nos. 2007C0003Z and 2006C0034M) and the National Hi-New Technology Research and Devel- opment Plan of China (Grant No. 2008AA101001). |
| 原文出处 | 2010532267.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4361]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China 2.Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China 3.Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China 4.Yunnan Institute of Buffalo Science and Technology, Kunming 650021, China 5.Animal Husbandry and Veterinary Station of Luxi city, Luxi 678400, China 6.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Miao YW,Wu GS,Wang L,et al. The role of MC1R gene in buffalo coat color[J]. SCIENCE CHINA-LIFE SCIENCES,2010,53(2):267-272. |
| APA | Miao YW.,Wu GS.,Wang L.,Li DL.,Tang SK.,...&Zhang YP[*].(2010).The role of MC1R gene in buffalo coat color.SCIENCE CHINA-LIFE SCIENCES,53(2),267-272. |
| MLA | Miao YW,et al."The role of MC1R gene in buffalo coat color".SCIENCE CHINA-LIFE SCIENCES 53.2(2010):267-272. |
入库方式： OAI收割
来源：昆明动物研究所
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