Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication
文献类型：期刊论文
| 作者 | vonHoldt BM1; Pollinger JP1; Lohmueller KE2; Han EJ3; Parker HG4; Quignon P4; Degenhardt JD2; Boyko AR2; Earl DA5; Auton A2 |
| 刊名 | NATURE
 |
| 出版日期 | 2010 |
| 卷号 | 464期号:7290页码:898-U109 |
| ISSN号 | 0028-0836 |
| 通讯作者 | rwayne@ucla.edu |
| 合作状况 | 其它 |
| 英文摘要 | Advances in genome technology have facilitated a new understanding of the historical and genetic processes crucial to rapid phenotypic evolution under domestication(1,2). To understand the process of dog diversification better, we conducted an extensive genome-wide survey of more than 48,000 single nucleotide polymorphisms in dogs and their wild progenitor, the grey wolf. Here we show that dog breeds share a higher proportion of multi-locus haplotypes unique to grey wolves from the Middle East, indicating that they are a dominant source of genetic diversity for dogs rather than wolves from east Asia, as suggested by mitochondrial DNA sequence data(3). Furthermore, we find a surprising correspondence between genetic and phenotypic/functional breed groupings but there are exceptions that suggest phenotypic diversification depended in part on the repeated crossing of individuals with novel phenotypes. Our results show that Middle Eastern wolves were a critical source of genome diversity, although interbreeding with local wolf populations clearly occurred elsewhere in the early history of specific lineages. More recently, the evolution of modern dog breeds seems to have been an iterative process that drew on a limited genetic toolkit to create remarkable phenotypic diversity. |
| 收录类别 | 其他 |
| 资助信息 | Grants fromNSFandNIH(R.K.W.;C.D.B.andJ.N.),thePolish Ministry of Science and Higher Education (M.P. and W.J.), European Nature Heritage Fund EURONATUR (W.J.), National Basic Research Program of China (Y.-p.Z.), and Chinese Academy ofSciences (Y.-p.Z.)supported this research. J.N. was supported by the Searle Scholars Program. B.M.vH. was supported by a NIH Training Grant in Genomic Analysis and Interpretation. K.E.L. was supported by a NSF Graduate Research Fellowship. E.A.O., D.S.M., T.C.S., A.E. and H.G.P. are supported by the intramural program of the National Human Genome Research Institute. M.P. was supported by the Foundation for Polish Science. |
| 原文出处 | 2010464898.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4363]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Department ofEcologyand Evolutionary Biology,621Charles E. Young DriveSouth,University of California, Los Angeles, California90095, USA 2.Department of Biological Statistics andComputationalBiology,CornellUniversity,Ithaca,NewYork14853-2601,USA 3.DepartmentofBiostatistics,UniversityofCalifornia,LosAngeles,California14853,USA 4.Cancer GeneticsBranch,NationalHumanGenomeResearchInstitute,NationalInstitutesofHealth,Bethesda,Maryland20892,USA 5.DepartmentofBiomolecularEngineering,Universityof California, Santa Cruz, California 95064, USA 6.Department of Zoology, Tel Aviv University, Tel Aviv 69978, Israel 7.Museum and Institute of Zoology, Polish Academy of Sciences, Wilcza 64, 00-679 Warszawa, Poland 8.Mammal Research Institute, Polish Academy of Sciences, 17-230 Bialowieza, Poland 9.Instituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), 40064 Ozzano Emilia (B), Italy 10.Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616, USA |
| 推荐引用方式 GB/T 7714 | vonHoldt BM,Pollinger JP,Lohmueller KE,et al. Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication[J]. NATURE,2010,464(7290):898-U109. |
| APA | vonHoldt BM.,Pollinger JP.,Lohmueller KE.,Han EJ.,Parker HG.,...&Novembre J.(2010).Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication.NATURE,464(7290),898-U109. |
| MLA | vonHoldt BM,et al."Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication".NATURE 464.7290(2010):898-U109. |
入库方式： OAI收割
来源：昆明动物研究所
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