Intriguing Balancing Selection on the Intron 5 Region of LMBR1 in Human Population
文献类型：期刊论文
| 作者 | He F1,3; Wu DD1,3; Kong QP1; Zhang YP[*]1,2 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2010 |
| 卷号 | 8期号:3页码:e2948 |
| 通讯作者 | zhangyp1@263.net.cn |
| 合作状况 | 其它 |
| 英文摘要 | Background: The intron 5 of gene LMBR1 is the cis-acting regulatory module for the sonic hedgehog (SHH) gene. Mutation in this non-coding region is associated with preaxial polydactyly, and may play crucial roles in the evolution of limb and skeletal system. Methodology/Principal Findings: We sequenced a region of the LMBR1 gene intron 5 in East Asian human population, and found a significant deviation of Tajima's D statistics from neutrality taking human population growth into account. Data from HapMap also demonstrated extended linkage disequilibrium in the region in East Asian and European population, and significantly low degree of genetic differentiation among human populations. Conclusion/Significance: We proposed that the intron 5 of LMBR1 was presumably subject to balancing selection during the evolution of modern human. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Key State Research Program of China (2006CB943900), Science and Technology Committee of Yunnan Province and the National Natural Science Foundation of China. |
| 语种 | 英语 |
| 公开日期 | 2010-11-02 |
| 源URL | [http://159.226.149.42:8088/handle/152453/6352]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_分子人类学 昆明动物研究所_进化与发育转录组学 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming, China 3.Graduate School of the Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | He F,Wu DD,Kong QP,et al. Intriguing Balancing Selection on the Intron 5 Region of LMBR1 in Human Population[J]. PLOS ONE,2010,8(3):e2948. |
| APA | He F,Wu DD,Kong QP,&Zhang YP[*].(2010).Intriguing Balancing Selection on the Intron 5 Region of LMBR1 in Human Population.PLOS ONE,8(3),e2948. |
| MLA | He F,et al."Intriguing Balancing Selection on the Intron 5 Region of LMBR1 in Human Population".PLOS ONE 8.3(2010):e2948. |
入库方式： OAI收割
来源：昆明动物研究所
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