Large-Scale mtDNA Screening Reveals a Surprising Matrilineal Complexity in East Asia and Its Implications to the Peopling of the Region
文献类型：期刊论文
| 作者 | Kong QP[*]1,2; Sun C1; Wang HW3; Zhao MA1,2; Wang WZ1,2; Zhong L3; Hao XD1,2; Pan H1; Wang SY4; Cheng YT1,2 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2011 |
| 卷号 | 28期号:1页码:513-522 |
| 关键词 | mtDNA lineage matrilineal complexity peopling East Asia |
| 通讯作者 | kongqp@yahoo.com.cn ; zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | In order to achieve a thorough coverage of the basal lineages in the Chinese matrilineal pool, we have sequenced the mitochondrial DNA (mtDNA) control region and partial coding region segments of 6,093 mtDNAs sampled from 84 populations across China. By comparing with the available complete mtDNA sequences, 194 of those mtDNAs could not be firmly assigned into the available haplogroups. Completely sequencing 51 representatives selected from these unclassified mtDNAs identified a number of novel lineages, including five novel basal haplogroups that directly emanate from the Eurasian founder nodes (M and N). No matrilineal contribution from the archaic hominid was observed. Subsequent analyses suggested that these newly identified basal lineages likely represent the genetic relics of modern humans initially peopling East Asia instead of being the results of gene flow from the neighboring regions. The observation that most of the newly recognized mtDNA lineages have already differentiated and show the highest genetic diversity in southern China provided additional evidence in support of the Southern Route peopling hypothesis of East Asians. Specifically, the enrichment of most of the basal lineages in southern China and their rather ancient ages in Late Pleistocene further suggested that this region was likely the genetic reservoir of modern humans after they entered East Asia. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from National Basic Research Program of China (No. 2007CB507405), Natural Science Foundation of China (30621092, 30900797, and 30925021), Yunnan Province, and the Chinese Academy of Sciences. |
| 语种 | 英语 |
| 公开日期 | 2010-12-17 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6541]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_分子进化基因组学 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_生命条形码中心 昆明动物研究所_两栖爬行类多样性与进化 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China 3.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming, China 4.Shenzhen People’s Hospital, Clinical Medical College of Jinan University, Shenzhen, China 5.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China |
| 推荐引用方式 GB/T 7714 | Kong QP[*],Sun C,Wang HW,et al. Large-Scale mtDNA Screening Reveals a Surprising Matrilineal Complexity in East Asia and Its Implications to the Peopling of the Region[J]. MOLECULAR BIOLOGY AND EVOLUTION,2011,28(1):513-522. |
| APA | Kong QP[*].,Sun C.,Wang HW.,Zhao MA.,Wang WZ.,...&Zhang YP[*].(2011).Large-Scale mtDNA Screening Reveals a Surprising Matrilineal Complexity in East Asia and Its Implications to the Peopling of the Region.MOLECULAR BIOLOGY AND EVOLUTION,28(1),513-522. |
| MLA | Kong QP[*],et al."Large-Scale mtDNA Screening Reveals a Surprising Matrilineal Complexity in East Asia and Its Implications to the Peopling of the Region".MOLECULAR BIOLOGY AND EVOLUTION 28.1(2011):513-522. |
入库方式： OAI收割
来源：昆明动物研究所
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